Antibody-drug conjugates (ADC) are highly potent and selective anti-tumor drugs, combining the specific targeting of mAbs with the potency of small molecule toxic payloads. Here, we employed enzymatic, site-specific conjugation to generate homogenous ADCs based on a derivative of the highly potent...
Anthracyclines have a complex mechanism of action including inhibition of enzymes such as topoisomerase II, resulting in DNA double-strand breaks, intercalation into DNA and also generation of reactive oxygen species.1 The anthracycline drugs have a quinone that undergoes reduction to a semi- quinone-...
We first assessed the sensitivity of a panel of malignant T-cell lines (HH, cutaneous TCL; SUP-T1, lymphoblastic TCL; KARPAS-299, ALCL; JURKAT and HD-MAR-2, T-cell leukaemia) to CHOP, a combination of drugs reflecting the regimen used in patients.13 Escalating doses of CHOP were used...
Advanced-stage follicular lymphoma in the rituximab era: when should patients receive anthracy- cline-based chemotherapy? Drugs 2009;69:1727-1737.RuthPettengell. (2009) Advanced-Stage Follicular Lymphoma in the Rituximab Era. Drugs 69 , 1727-1737 /...
More recently, several case-reports and small series have suggested that anti-angiogenic drugs may have activity in SFT. Park et al. report...Constantinidou A, Jones RL, Olmos D, Thway K, Fisher C, Al-Muderis O: Conventional anthracycline-based chemotherapy has limited efficacy in solitary ...
13, Pages 15536-15564: Cancer Cell Response to Anthracyclines Effects: Mysteries of the Hidden Proteins Associated with These Drugs A comprehensive proteome map of T-lymphoblastic leukemia cells and its alterations after daunorubicin, doxorubicin and mitoxantrone treatments was monitore... Tyleckova,...
ABCB1 encodes the P-glycoprotein – membrane transport protein – responsible for the cellular efflux of drugs, xenobiotics, cellular metabolites and anticancer agents, being crucial in response to chemotherapy. Our aim was to determine whether C1236T (rs1128503) and G2677 T/A (rs2032582) ...
doi:10.1161/circ.150.suppl_1.4146993Cardio-oncologyIntroduction:Anthracyclines (AC), a class of chemotherapeutic drugs, are used to treat various cancers, including breast cancer (BC). However, AC cause dose-dependent cardiac toxicity. Practice guidelines list pre-existing cardiomyopathy as a risk ...
These mean doses declined during cycles 4-6 to 72.4%, 74.4%, and 71.8% for the three drugs respectively.Montemurro FAglietta MThe Lancet
INDUCTION chemotherapyCELL deathBackground: Although anthracyclines are the first-line chemotherapy drugs for treating non-M3 acute myeloid leukaemia (AML), their efficacy remains limited. It is important to identify factors that influence the efficacy of anthracyclines against AML. Mitoc...