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1. In human cells, ANP32A and ANP32B serve redundant roles to support influenza polymerase9. In chicken cells, ANP32A is solely responsible for the pro-viral function while ANP32B is inactive10. In both species, ANP32E is suggested to have an antiviral effect11. Replication of the viral g...
better survival rate in follicular lymphoma.21 Previously we reported that ANP32B, also designated as PHAPI2 or SSP29, is a negative prognostic indicator for human breast cancer.22 Full analysis of the expression and functional role of ANP32B in cancer progression has still not been undertaken....
Download: Download full-size image Fig. 2. Cell cycle analysis: Flow cytometry analysis of propidium iodide stained cells to illustrate the percentage of cells in each phase of the cell cycle (A, C, E) and BrdU incorporation (B, D, F) to determine the percentage of cells in the S-phas...
Note: the experiments performed to measure NT-proANP in cell culture supernatant samples has not undergone a full validation according to ICH guidelines. However, our performance check suggests that cell culture supernatant samples can be measured with this ELISA. For more information please refer to...
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In the present work we aimed at exploring the impact of C2238/αANP (mutant form) on atherosclerosis-related pathways. As a first step, an atherosclerosis gene expression macroarray analysis was performed in vascular smooth muscle cells (VSMCs) exposed to either T2238/αANP (wild type) or ...
Full size image Then, we evaluated the mechanisms through which C2238/αANP induces platelet activation and aggregation. We previously demonstrated that C2238/αANP binds to NPR-C with a high affinity and activates it in a deregulated manner. On the other hand, it modulates NPR-A similarly to...