The human genome is pervasively transcribed and produces a wide variety of long non-coding RNAs (lncRNAs), constituting the majority of transcripts across human cell types. Some specific nuclear lncRNAs have been shown to be important regulatory components acting locally. As RNA-chromatin interaction...
To validate the results of scCATCH, three independent scRNA-seq datasets, which were not recorded in the CellMatch database, were used, and cell types in these three datasets were identified or validated viaFACS,in situhybridization, or IHC. In particular, the Chen dataset (Chen et al., 201...
## >> gpt-4o-mini is being used with a temperature setting of 0 ## >> Response: T cell ## >> Response: Monocyte/Macrophage ## >> Response: CD4+ T cells ## >> Response: B cell ## >> Response: Cytotoxic T lymphocyte (CTL) ## >> Response: Cytotoxic T lymphocytes (CTLs) #...
Untargeted metabolomics experiments rely on spectral libraries for structure annotation, but, typically, only a small fraction of spectra can be matched. Previous in silico methods search in structure databases but cannot distinguish between correct and incorrect annotations. Here we introduce the COSMIC ...
of cell types across complex annotation hierarchies. To demonstrate the power ofdevCellPy, we construct a murine cardiac developmental atlas from published datasets encompassing 104,199 cells from E6.5-E16.5 and traindevCellPyto generate a cardiac prediction algorithm. Using this algorithm, we ...
We reasoned that hESC differentiation models combined with epigenomic enhancer annotation and sequence analysis of the underlying DNA can be used as an unbiased approach to identify main TFs driving gene expression in transient cell types arising during human development. As a proof of concept, we ...
Notably, individual steps in complex metabolic pathways frequently require specific environments, that are achieved only by strict compartmentalization across various tissues, between specific cell types, among the different organelles. Membrane transporters are crucial mediators of metabolic processes, ...
A common method for presenting and studying biological interaction networks is visualization. Software tools can enhance our ability to explore network visualizations and improve our understanding of biological systems, particularly when these tools offe
Disclosed herein are compositions and methods for targeting a novel regulatory element of a gene. The compositions may be used in methods of modifying growth of a cell, decreasing c
In addition to a desktop client156, embodiments of the present invention provide for the use and implementation of small device clients156. In one embodiment, a small device client156allows hand held devices, such as, e.g., a pocket personal computer, personal digital assistants, and cell phon...