annotation of cell typesregenerationIn mammals, cartilage tissue has a low potential for regeneration. Typically, the defect site is replaced by connective tissue. The Acomys cahirinus mouse is a relatively new model for studying tissue regeneration processes, specifically the elastic cartilage of the ...
Recent advances in single-cell technologies have enabled the characterization of epigenomic heterogeneity at the cellular level. Computational methods for automatic cell type annotation are urgently needed given the exponential growth in the number of ce
Annotating cell types is a critical step in single-cell RNA sequencing (scRNA-seq) data analysis. Some supervised or semi-supervised classification methods have recently emerged to enable automated cell type identification. However, comprehensive evaluations of these methods are lacking. Moreover, it ...
Manual annotation of cell types, especially cell subtypes, relies on marker genes selection. However, specificity of marker genes is determined by comparing with the other cell types in the same dataset. Thus, across different datasets, the same cell may have different marker gene sets, thus anno...
cell RNA-seq data, based on a score annotation model combining differentially expressed genes and confidence levels of cell markers in databases. Evaluation on real scRNA-seq datasets that SCSA is able to assign the cells into the correct types at a fully automated mode with a desirable ...
Joint annotation of chromatin state and chromatin conformation reveals relationships among domain types and identifies domains of cell type-specific expressionThe genomic neighborhood of a gene influences its activity, a behavior that is ... MW Libbrecht,F Ay,MM Hoffman,... - Cold Spring Harbor La...
Individual tissues and cell types of each organ system were manually reviewed by experts in each organ system. The name of each tissue and cell type from different sources were standardized, and the corresponding cell markers were integrated. Both mouse and human genes were included in the data...
Create a text box annotation with multiline text by setting the String property to a cell array. Each element of the cell array displays on a separate line. Force the box to fit tightly around the text by setting the FitBoxToText property to 'on'. Get figure plot(1:10) dim = [0.2...
Our results include a large enrichment of heritability in conserved regions across many traits; a very large immunological disease-specific enrichment of heritability in FANTOM5 enhancers; and many cell-type-specific enrichments including significant enrichment of central nervous system cell types in body...
Automatic cell type annotation methods are increasingly used in single-cell RNA sequencing (scRNA-seq) analysis due to their fast and precise advantages. However, current methods often fail to account for the imbalance of scRNA-seq datasets and ignore in