SARS-CoV-2COVID-19cell modelsanimal modelsorganoidsBasic research on SARS-CoV-2 is essential to understand its detailed pathophysiology and identify best drug targets. Models that can faithfully reproduce the viral life cycle and reproduce the pathology of COVID-19 are required. Here, we briefly...
This Comment discusses the main animal models that have had a key role in our understanding of the immune and viral dynamics of SARS-CoV-2. This is a preview of subscription content, access via your institution Access options Access Nature and 54 other Nature Portfolio journals Get Nature+...
SARS-CoV-2 is the novel coronavirus responsible for the outbreak of COVID-19, a disease that has spread to over 100 countries and, as of the 26th July 2020, has infected over 16 million people. Despite the urgent need to find effective therapeutics, research on SARS-CoV-2 has been ...
SARS‐CoV‐2COVID‐19ARDScoronavirusThe coronavirus disease 2019 (COVID) pandemic caused by SARS〤oVinfections has led to substantial unmet need for treatments, many of which will require testing in appropriate animal models of this disease. Vaccine trials are already underway, but there remains ...
There is an urgent need for new animal models of SARS CoV-2 infection to improve research and drug development. This brief commentary examines the deficits of current models and proposes several improved alternates. The existing single transgene mouse models poorly mimic the clinical features of CO...
Research7 May 2025 Differential responses of lung and intestinal microbiota to SARS-CoV-2 infection: a comparative study of the Wuhan and Omicron strains in K18-hACE2 Tg mice Chae Won Kim, Keun Bon Ku, Insu Hwang, Hi Eun Jung, Kyun-Do Kim and Heung Kyu Lee ...
In this frame, during 2020, animal models have been vital for the current global health priority of coronavirus disease 2019 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Indeed, neutralizing monoclonal antibodies derived from convalescence donors have been tested in Syrian...
The current COVID-19 pandemic, caused by the highly contagious respiratory pathogen SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2), has alrea
Studying SARS-CoV-2 A challenge of the pandemic has been the lack of animal models that could contribute to the study of human immune cells in SARS-CoV-2 viral infections. Such animal models, however, are starting to become available. For example, Charles River Laboratories has developed h...
The COVID-19 pandemic, which was caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become a worldwide health crisis due to its transmissibility. SARS-CoV-2 infection results in severe respiratory illness and can lead to signific