Speth RC, Wamsley JK, Gehlert DR, Chernicky CL, Barnes KL, Ferrario CM (1985) Angiotensin II receptor localization in the canine CNS. Brain Res 326: 137–143 View ArticleSpeth RC, Wamsley JK, Gehlert DR, et al: Angiotensin II receptor localization in the canine CNS. Brain Res 326:137...
The angiotensin II type 2 receptor (encoded by AGTR2 gene; location: Xq22–q23) is a component of the renin–angiotensin system (RAS), which is considered to be one of the regulators of skeletal muscle growth and differentiation. RAS is linked with calcineurin, MAPK, Akt, nitric oxide (NO...
Central infusion of angiotensin II type 2 receptor agonist compound 21 attenuates doca/nacl-induced hypertension in female rats. Oxid Med Cell Longev. 2016;2016:3981790. PubMed Google Scholar Blanch GT, Freiria-Oliveira AH, Speretta GF, Carrera EJ, Li H, Speth RC, et al. Increased ...
type 1 angiotensin II receptor IL-6: interleukin-6 iRAS: intravascular renin-angiotensin system JNK: cJun terminal kinase IRAS: local renin-angiotensin system NF-кB: nuclear factor кB PKC: protein kinase C STATs: signal transducers and activators of transcription TNFα: tumor necrosi...
Angiotensin II receptor binding sites were densely concentrated in the superficial layers of the dorsal horn. Considerably lower densities of binding sites were present in the remaining gray matter. Effects of microiontophoretically applied AII on lumbar spinal cord cells did not vary with location ...
Angiotensin receptor blockerInflammatory bowel diseasePreclinical data demonstrate that activation of the renin鈥揳ngiotensin system (RAS) contributes to mucosal inflammation, and RAS inhibition by angiotensin-converting-enzyme inhibitors (ACEI) and angiotensin receptor blockers (ARB) improves colitis in ...
Here, using protein engineering, pharmacological assays and structural studies, we develop maternally selective heavy-chain-only antibody (‘nanobody’) antagonists against the angiotensin II type I receptor and uncover the unusual molecular basis of their receptor antagonism. We further show that our ...
Angiotensin II type I receptor associated protein; AT1 receptor-associated protein; ATI receptor associated protein; ATRAP; ATRAP_HUMAN; MGC29646; OTTHUMP00000002269; OTTHUMP00000002270; OTTHUMP00000002271; Type 1 angiotensin II receptor associated protein; Type-1 angiotensin II receptor-associated protei...
lung fibrosis, scleroderma, anxiety, cognitive disorders, complications of treatments with immunosuppressive agents, and other diseases known to be related to the renin-angiotensin system, by administering an angiotensin II receptor antagonist of the invention to a patient having one or more of these ...
antibodies and anti-idiotypic antibodies have been prepared to the Ang II receptor, from which it has been postulated that the receptor has a molecular weight of from 60 to 95 kD, and 63 kD respectively, to date no-one has succeeded in preparing a monoclonal antibody to this receptor. ...