In this series, the authors present cases of men being treated with androgen deprivation therapy, and highlight their management to prevent and treat associated toxicities. This fifth article will consider the management of the metabolic syndrome. Copyright © 2014 John Wiley & SonsSubhra Chowdhury...
Prostate cancer is highly prevalent worldwide. Androgen deprivation therapy (ADT) remains the treatment of choice for incurable prostate cancer, but majority of patients develop disease recurrence following ADT. There is therefore an urgent need for earl
inhibition in vivo. Our data suggest that ADT can functionally impair HR prior to the development of castration resistance and that, this potentially could be exploited therapeutically using PARP inhibitors in combination with androgen-deprivation therapy upfront in advanced or high-risk prostate cancer...
Lifestyle interventions involving exercise training offset the adverse effects of androgen deprivation therapy in men with prostate cancer. Yet provision of integrated exercise pathways in cancer care is sparse. This study assessed the feasibility and acceptability of an embedded supervised exercise training...
The median time to CRPC was longer in patients that received radical therapy than among those treated with androgen deprivation alone (34.2 vs 15.3 mo; hazard ratio [HR] 0.37; 95% CI 0.17–0.81; p = 0.014). Nuclear AR-V7 expression at HSPC biopsy was associated with time to castration ...
Background: Androgen deprivation therapy (ADT) is used to delay tumour development and improve survival in patients with prostate cancer. However, several randomized controlled trials and observational studies have suggested that ADT may increase the risk of cardiovascular events. Objective: The aim of...
A multi-centre investigation of delivering national guidelines on exercise training for men with advanced prostate cancer undergoing androgen deprivation therapy in UK NHS. PLoS One. 2018;13(7):e0197606. https://doi.org/10.1371/journal.pone.0197606. Article CAS PubMed PubMed Central Google ...
androdgen deprivation therapy (ADT)bilateral sub-capsular orchidectomy (BSCO)prostate cancerObjective:Rapid control of the disease is essential in the management of patients with critical and symptomatic metastatic prostate cancer. Pharmacological castration has become the main form of androgen-deprivation...
Androgen receptor gene and hormonal therapy failure of prostate caner. Am J Pathol. 1998;152:1–9. CAS PubMed PubMed Central Google Scholar Wadosky KM, Koochekpour S. Molecular mechanisms underlying resistance to androgen deprivation therapy in prostate cancer. Oncotarget. 2016;7:64447–70. ...
Institute of Systems, Molecular and Integrative Biology, University of Liverpool & Clatterbridge Centre NHS Foundation Trust, Liverpool, UK Carlo Palmieri Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK Jason S. Carroll ...