该抗体针对着丝粒蛋白,与局限性SSc相关,在弥漫性SSc、SS、RA、健康人群中水平较低;雷诺氏综合征患者中发现该抗体提示SSc发生。 常用检测方法:IFA,灵敏度:<40%,特异性:>97%。 8.抗组氨酰tRNA合成酶(Jo-1)抗体 15%-25%的皮肌炎(DM)和多发性肌炎(PM)患者中存在这类抗体,与抗合成酶综合征相关,表现雷诺现象、...
The indirect immunofluorescence assay on HEp-2cells (HEp-2 IFA), historically known as the antinuclear antibody test, is a method capable of detecting a wide spectrum of autoantibodies. A positive HEp-2 IFA test is part of the classification criteria for systemic lupus erythematosus (SLE) and ...
Antinuclear antibody testing – misunderstood or misbegotten? Nat Rev Rheumatol. 2017 Aug;13(8):495-502 7. RL Humbel. Detection of antinuclear antibodies by immunofluorescence. In: van Venrooij, Maini RN eds. Manual of Biological Markers of Disease. Dordrecht, The Netherlands: Kluwer; 1993: A2...
The ANA Hep Screen ELISA assay allows for collective and simultaneous screening for the autoantibodies of major significance in one microwell, and effectively eliminates the need for individual interpretation that is inherent in IFA technology. 上海玉博生物技术有限公司在为生命科学领域提供丰富的产品与信息...
常用检测方法:IFA,灵敏度:<40%,特异性:>97%。 8.抗组氨酰tRNA合成酶(Jo-1)抗体 15%-25%的皮肌炎(DM)和多发性肌炎(PM)患者中存在这类抗体,与抗合成酶综合征相关,表现雷诺现象、发烧、关节炎、间质性贫血、肺部疾病。 检测的黄金标准是免疫沉淀(IP),拥有最高的灵敏度和特异性。
常用检测方法:IFA,灵敏度:<40%,特异性:>97%。 8.抗组氨酰tRNA合成酶(Jo-1)抗体 15%-25%的皮肌炎(DM)和多发性肌炎(PM)患者中存在这类抗体,与抗合成酶综合征相关,表现雷诺现象、发烧、关节炎、间质性贫血、肺部疾病。 检测的黄金标准是免疫沉淀(IP),拥有最高的灵敏度和特异性。
As a result, different systems have been developed which automate part of or the complete IFA method and reading process.ObjectivesThis study compares 2 commercially available HEp-2 antinuclear antibody (ANA) indirect fluorescent antibody (IFA) assays using a sensitivity panel (120 clinically ...
Use of Computer-Aided Immunofluorescence Microscopy (CAIFM) for Interpretation of Antinuclear Antibody (ANA) Pattern and TiterFluorescent Antinuclear AntibodiesImmunofluorescence MicroscopyAutoimmune Diseasecomputer-assistedinterpretationThe assessment of antinuclear antibodies (ANA) by indirect immunofluorescence (IFA)...
THU0337 Evaluation of High-Throughput Platforms for Digital Antinuclear Antibody (ANA) Indirect Immunofluorescence (IFA) ScreeningBoll Soc Ital Biol Sper. 1975 Nov 15;51(21):1537-40.doi:10.1136/annrheumdis-2013-eular.865Zarabpouri, F.Zambales, M.-L. V....
the presence of an antinuclear antibody (ANA) is an important element, with new criteria from the American College of Rheumatology and European League against Rheumatism positioning ANA positivity by an immunofluorescence assay on HEp2-cells (HEp2-IFA) or by an equivalent solid phase assay as the...