In this chapter, I discuss the molecular pathway that controls necrosis and how it contributes to different inflammatory diseases.doi:10.1007/978-1-4614-9302-0_10Francis Ka-Ming ChanSpringer New YorkChan FK-M. Programmed necrosis/necroptosis: an inflammatory form of cell death . Cell Death . ...
An integral perspective of canonical cigarette and e-cigarette-related cardiovascular toxicity based on the adverse outcome pathway framework RuiyangDing, ...JunchaoDuan, inJournal of Advanced Research, 2023 Molecular initiating event (KE 151): Release of inflammatory cytokines ...
Goal of the perspective Exploring necroptosis as an indicator of therapeutic resistance in viral-induced well-differentiated oral squamous cell carcinoma (OSCC) is to elucidate its potential role in predicting treatment outcomes and guiding therapeutic decisions. By understanding the relationship between necr...
Although, our understanding of the precise signaling pathways that trigger cell-free Hb-related cell death is still limited, previous studies have hinted on inflammatory necroptosis, apoptosis and/or NFKB modulated inflammation [11, 13, 42]. Here, we show that exposure of the mixed glial cells ...
Regulation of Zfp36 by ISGF3 and MK2 restricts the expression of inflammatory cytokines during necroptosis stimulation Article Open access 08 August 2024 The STING1 network regulates autophagy and cell death Article Open access 02 June 2021 Introduction...
a pronounced immune response [33]. Conversely, necroptosis and pyroptosis are lytic types of cell death that generate pores in the plasma membrane leading to the release of the intracellular content, including cytokines and DAMPs, in the extracellular environment. This induces a strong inflammatory re...
The ancestral origins of the lytic cell death mode, necroptosis, lie in host defense. However, the dysregulation of necroptosis in inflammatory diseases has led to widespread interest in targeting the pathway therapeutically. This mode of cell death is executed by the terminal effector, the MLKL ps...
Sugarcane leaf polysaccharide exerts a therapeutic effect on cardiovascular diseases through necroptosis. Heliyon, 2023, 9(11): e21889. DOI:10.1016/j.heliyon.2023.e21889 30. Xu Y, Wang Q, Zou J, et al. CHD-related/specific mortality of 3.17 million people in a transitioning region: trends...
A decade of cell death studies: Breathing new life into necroptosis Pharmacology & Therapeutics Journal2021, Pharmacology & Therapeutics Imran Khan, ... IIana Chefetz 4.5 Inflammatory bowel disease Inflammatory bowel disease (IBD) is a group of syndromes that affect the integrity of the ...
Activation of the immune system by infections,trauma, stress, and other agents leads to the initiation of a series of cascades in the brain through the inflammatory pathway. In this connection, macrophages are also activated in the brain which may enter into the neuronal tissues to remove the ...