Chromosomes stained with certain dyes, commonly quinacrine (Q banding) or Giemsa (G banding), show a pattern of transverse bands of light and heavy staining that is characteristic for the individual chromosome. The basis of the differential staining, which is the same in most tissues, is not ...
2.6 The Extracellular Matrix The extracellular matrix (ECM) is a non-cellular macromolecular 3-D network structure, composed of elastin, fibronectin, laminins, proteoglycans/glycosaminoglycans and other glycoproteins, as well as numerous soluble factors (67). The matrix components bind to each other ...
The prognosis and prediction of adjuvant chemotherapy (ACT) response in early-stage non-small cell lung cancer (NSCLC) patients remain poor in this era of personalized medicine. We hypothesize that extracellular matrix (ECM)-associated components could b
Dynamic conformational changes play a major role in the function of proteins, including the ATP-Binding Cassette (ABC) transporters. Multidrug Resistance Protein 1 (MRP1) is an ABC exporter that protects cells from toxic molecules. Overexpression of
Glioblastoma is one of the most lethal cancers with current therapeutic options lacking major successes. This underlines the necessity to understand glioblastoma biology on other levels and use these learnings for the development of new therapeutic conce
of iMG’s (e.g. their phagocytic aptitude, their chemotactic responses, both central characteristic of primary human microglia), is limited. Furthermore, the manipulation of gene expression at large scale, crucial for understanding the molecular role of AD-linked genes, is problematic in iMG ...
The supramolecular conformation that keeps mucins interconnected in the mucus gel matrix is still uncertain. In the granule, a Ca-bonded matrix keeps mucus condensed. Upon exocytosis, Na/Ca exchange removes Ca bonds, triggering characteristic polymer gel phase transition and massive swelling (1). Fai...
In the genetic modification of MSCs, a constructed gene cassette is loaded into a vector for easy entry into the MSC. Once inside the MSC, it produces or overexpresses certain specific genes. The transgene expression could either remain constant resulting in characteristic synthesis of specific mole...
7. An approach to molecular characteristic of collagen mesh extracellular matrix in processed tissue banking, by diffractive techniqueIntroduction Preservation techniques are of fundamental support for conservation of tissue banking (TB) biological materials. However, controversial views remain on the effects...
For example, mammary gland epithelial cells cultured on Engelbreth–Holm–Swarm (EHS), a specialized matrix synthesized by EHS tumors with many of the properties of basement membranes, synthesized milk molecules and underwent the branching morphogenesis characteristic of mammary glands [1]. These and...