The formation of invadopodia is a characteristic of highly invasive cancer cells4. Invadopodia are elongated ventral membrane protrusions that are composed of a variety of proteins, such as actin filaments, actin-related protein-2/3 (Arp2/3) complex, neuronal Wiskott-Aldrich syndrome protein (N-W...
Theextracellular matrix(ECM) is a non-cellular macromolecular 3-D network structure, composed ofelastin,fibronectin,laminins, proteoglycans/glycosaminoglycans and otherglycoproteins, as well as numerous soluble factors(67). The matrix components bind to each other and tocell receptors, forming a complex...
The prognosis and prediction of adjuvant chemotherapy (ACT) response in early-stage non-small cell lung cancer (NSCLC) patients remain poor in this era of personalized medicine. We hypothesize that extracellular matrix (ECM)-associated components could b
7. An approach to molecular characteristic of collagen mesh extracellular matrix in processed tissue banking, by diffractive techniqueIntroduction Preservation techniques are of fundamental support for conservation of tissue banking (TB) biological materials. However, controversial views remain on the effects...
Glioblastoma is one of the most lethal cancers with current therapeutic options lacking major successes. This underlines the necessity to understand glioblastoma biology on other levels and use these learnings for the development of new therapeutic conce
As with other macromolecules, the elucidation of the primary structure (implying the sequence of monomeric units with the respective glycosidic linkages) is a pre-requisite. Depending on their primary structures and biosynthesis, polysaccharides may have single or multiple chains in characteristic helical...
(Dowe1987). The latter group is responsible for most damage to crops (Jansson and López-Llorca2004). It includes the root-knot nematodes (Meloidogynespp.) and the cyst nematodes (HeteroderaandGloboderaspp.). A characteristic feature of most phytoparasitic nematodes is their protractible stylet,...
today's academic and industrial researchers are both interested in the functional roles of gpcrs at the finest subtype level. this is mainly because each subtype demonstrates its own characteristic ligand binding property, coupling partners of trimeric g-proteins, and interaction partners of ...
SIS Wound Matrix The SIS Wound Matrix (OASIS Wound Matrix, Healthpoint Ltd, Ft Worth, Tex) is a naturally occurring ECM derived from the submucosal layers of the porcine jejunum. Porcine small intestine is subjected to manufacturing processes that render the material free of viral contaminants and...
For example, mammary gland epithelial cells cultured on Engelbreth–Holm–Swarm (EHS), a specialized matrix synthesized by EHS tumors with many of the properties of basement membranes, synthesized milk molecules and underwent the branching morphogenesis characteristic of mammary glands [1]. These and...