The formation of invadopodia is a characteristic of highly invasive cancer cells4. Invadopodia are elongated ventral membrane protrusions that are composed of a variety of proteins, such as actin filaments, acti
2.6 The Extracellular Matrix The extracellular matrix (ECM) is a non-cellular macromolecular 3-D network structure, composed of elastin, fibronectin, laminins, proteoglycans/glycosaminoglycans and other glycoproteins, as well as numerous soluble factors (67). The matrix components bind to each other ...
Since a spike cage has never been seen in any of the previous high-resolution structures, we investigated its presence in the closest AlgoCIS relatives, namely in MACs and T6SSiv. We analysed the sequences of Alg11 homologues and indeed found the characteristic extensions. Subsequent sub-tomogra...
7. An approach to molecular characteristic of collagen mesh extracellular matrix in processed tissue banking, by diffractive techniqueIntroduction Preservation techniques are of fundamental support for conservation of tissue banking (TB) biological materials. However, controversial views remain on the effects...
Glioblastoma is one of the most lethal cancers with current therapeutic options lacking major successes. This underlines the necessity to understand glioblastoma biology on other levels and use these learnings for the development of new therapeutic conce
A characteristic feature of most phytoparasitic nematodes is their protractible stylet, a spear-shaped hollow feeding organ that is used to puncture cells. Currently, the three most prevalent phytoparasitic nematodes in Europe are the beet cyst nematode Heterodera schachtii, the stem and bulb ...
As with other macromolecules, the elucidation of the primary structure (implying the sequence of monomeric units with the respective glycosidic linkages) is a pre-requisite. Depending on their primary structures and biosynthesis, polysaccharides may have single or multiple chains in characteristic helical...
It displays a super-helical fold similar to the one characteristic of the SLR family. However, the superposition of this TPR domain with HcpB highlights different super-helix parameters, consequence of different packing angles within and between the repeats. The region of specific ligand binding, ...
The enrichment of gelatinase in the extracellular matrix is a characteristic of mature microbial biofilms [106]. The high content of gelatinase in the biofilm matrix makes it a common target for biofilm microenvironment-responsive nanoparticles. Qiu et al. designed a gelatinase-responsive theranostic na...
For example, mammary gland epithelial cells cultured on Engelbreth–Holm–Swarm (EHS), a specialized matrix synthesized by EHS tumors with many of the properties of basement membranes, synthesized milk molecules and underwent the branching morphogenesis characteristic of mammary glands [1]. These and...