The blood–brain barrier and blood–spinal cord barrier (BSCB) limit the entry of plasma components and erythrocytes into the central nervous system (CNS). Pericytes play a key role in maintaining blood–CNS barriers. The BSCB is damaged in patients with amyotrophic lateral sclerosis (ALS). More...
Mutations in copper,zinc-superoxide dismutase (SOD) have been implicated in familial amyotrophic lateral sclerosis (FALS). We have investigated the breakdown of S-nitrosothiols by wild-type (WT) SOD and two common FALS mutants, alanine-4 valine (A4V) SOD and glycine-37 arginine (G37R) SOD....
and reproduction in any medium, provided the original work is properly cited. reprints and permissions about this article cite this article winkler, e.a., sengillo, j.d., sullivan, j.s. et al. blood–spinal cord barrier breakdown and pericyte reductions in amyotrophic lateral sclerosis. acta...