Amyotrophic Lateral Sclerosis is a devastating disorder characterized by the loss of motor neurons, and recent research has provided insights into the mechanisms of this disease and the potential for developing effective treatments. AI generated definition based on: Current Opinion in Pharmacology, 2002 ...
amyotrophic lateral sclerosis (ALSastrogliaendoplasmic reticulum (ERendoplasmic reticulum stressglial cellsglutamate transportersmitochondrial damagesuperoxide dismutase 1 (SOD1Summary There are many different possibilities that might be involved in amyotrophic lateral sclerosis (ALS). However, it may be that ...
11. Amyotrophic Lateral Sclerosis 来自 Wiley 喜欢 0 阅读量: 14 作者: R Crichton,R Ward 展开 摘要: Summary There are many different possibilities that might be involved in amyotrophic lateral sclerosis (ALS). However, it may be that the selective killing of motor neurons results from the ...
Amyotrophic lateral sclerosis (ALS), a progressive neurodegenerative disease whose pathophysiology isn’t understood, results in upper and lower motor neuron dysfunction. This neural damage leads to muscular atrophy, spasms, and fasciculations (involuntary muscle contractions). Muscle dysfunction begins in ...
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease where substantial heterogeneity in clinical presentation urgently requires a better stratification of patients for the development of drug trials and clinical care. In this study we explored stratification through a crowdsourcing approach...
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease involving loss of motor neurons and having no known cure and uncertain etiology. Several studies have drawn connections between altered retrotransposon expression and ALS. Certain features of the LINE-1 (L1) retrotransposon-encoded ...
The lack of biomarkers for early diagnosis, clinical stratification and to monitor treatment response has hampered the development of new therapies for amyotrophic lateral sclerosis (ALS), a clinically heterogeneous neurodegenerative disorder with a vari
Two decades after the discovery that 20% of familial amyotrophic lateral sclerosis (ALS) cases were linked to mutations in the superoxide dismutase-1 (SOD1) gene, a substantial proportion of the remainder of cases of familial ALS have now been traced to an expansion of the intronic hexanucleoti...
Amyotrophic lateral sclerosis (ALS) remains a fatal neurodegenerative disease characterized by the progressive degeneration of both the upper and lower motor neurons (UMNs and LMNs). There is an incomplete understanding of the disease pathophysiology and current interventions only mildly slow disease prog...
CONNECTED ACADEMIC WORLD 04:31am 21 Apr, 2016 Human Cu/Zn superoxide dismutase (SOD1) overexpression in mice causes mitochondrial vacuolization, axonal degeneration, and premature motoneuron death and accelerates motoneuron disease in mice expressing a familial amyotrophic lateral sclerosis mutant SOD1....