It is widely known that, in higher eukaryotes, the amyloid form of a number of proteins that control neuronal activity leads to the shutdown of their funct
like tentacles, in a so-called cross-beta structure. Scientists disagree whether it is the clumps that kill neurons in the brain or the fibrils. Grigorieff wants to discover which part of the amyloid structure is toxic; that would be an important step...
Finally, we introduce alternative methods of removing Aβ including the “CSF-sink” therapeutic strategy. As soluble peptides are in constant equilibrium between the ISF and the CSF, altering the levels of Aβ oligomers in the CSF would also alter the levels of such proteins in the brain ...
Amyloids applied into the trachea may either be disseminated through the circulation and cross the blood-brain barrier to access the brain, initiate feed-forward amyloid transmissibility among cells of the blood-brain barrier or access the brain in other ways. Nevertheless, lung-derived amyloids ...
in evolution remain almost unexplored. Using bioinformatics approaches and summarizing the data published previously, we have shown that amyloid fibrils performing similar functions in different organisms have been arising repeatedly and independently in the course of evolution. On the other hand, we show...
Interactions of - amyloids with the blood-brain barrier. de la Torre, JC.; Hachinski, V., editors. Ann. N.Y. Acad. Sci.; New York, NY: 1997b. p. 190-199.[826]WILLIAM A., BANKSABBA J., KASTINLAWRENCE M., MANESSMARIAN F., BANKSMARCOS, SHAYOROBERT N., McLAY. (1997) ...
have a role in innate immunity against herpes virus brain infections5. More specifically, Eimer et al.5showed that Aβ interacts with herpes glycoproteins, thereby inducing Aβ amyloid formation. The seeding of Aβ aggregation leads to an entrapment of the viral particles, which results in an ...
Moreover, comparisons of in vitro generated spontaneous rPrP fibrils to brain-derived PrPRes fibrils by FTIR spectroscopy and H/D exchange mass spectrometry indicate that major refolding of both the flexible N-terminal and helical C-terminal domains of PrPC occur in forming fully infectious PrPRes...
Glycation in neuropathies 1995, Trends in Neurosciences Gene expression and cellular content of cathepsin D in Alzheimer's disease brain: Evidence for early up-regulation of the endosomal-lysosomal system 1995, Neuron Show abstract A soluble form of prion protein in human cerebrospinal fluid: Implicati...
protein- any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of polymers of amino acids; essential in the diet of animals for growth and for repair of tissues; can be obtained from meat and eggs and milk and legumes; "a diet high ...