(2004) Atherosclerosis, vascular amyloidosis and brain hypoperfusion in the pathogenesis of sporadic Alzheimer's disease. Neurol Res 2004; 26: 525-539. [Crossref]Kalback W, Esh C, Castano EM, Rahman A, Kokjohn T, Luehrs DC, Sue L, Cisneros R, Gerber F, Richardson C, Bohrmann B, ...
brain tissue rarely is done. The biopsy could injure the brain and while the results might provide a diagnosis, it would be unlikely to change treatment (because there is no effective treatment for amyloid in the brain). When amyloidosis is diagnosed or highly suspected, additional blood and ...
Amyloid deposits can damage the nerves outside your brain and spinal cord, called the peripheral nerves. The peripheral nerves carry information from your brain and spinal cord to the rest of your body. For example, they make your brain perceive pain if you burn your hand or stub your toes...
Your heart, brain, kidneys, liver, spleen, digestion, and nervous system can all be affected. Severe forms of amyloidosis can lead to organ failure and be life-threatening.What are the signs and symptoms of amyloidosis?You may not have signs or symptoms until the condition is considered ...
biochemistry of the amyloid diseases have begun to provide information regarding the age-related amyloidoses. In humans age-related amyloidosis tends to occur in certain organ systems as distinct pathologic entities, most notably the brain, heart, pancreas, aorta, seminal vesicles and osteoarticular ...
Amyloidosis is a group of diseases characterized by deposition of amyloid fibrils in soft tissues and organs. These fibrils all have the similar characteristics that distinguish them as amyloid. More than 24 proteins have been identified to form amyloid
It is argued that brain microglia, and/or astrocytes are the most likely candidates to the regulatory function of amyloid deposit in the brain. These cells could act by modulation of either the hydrolysis of the precursor protein during amyloidogenesis or the resorption of amyloid fibrils, which...
Two types of familial cerebral amyloid angiopathy or hereditary cerebral hemorrhage with amyloidosis (HCHWA) have been described: the Icelandic type (HCHWA-I), and the Dutch type (HCHWA-D). Both are autosomal-dominant forms of amyloidosis restricted to the small vasculature of the brain and cli...
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and will be the subject of this chapter. AA amyloidosis was described secondary to chronic infections as well, in the early twentieth century. AL amyloidosis, which is seen generally in the elderly, is the most common type of amyloidosis in the developed countries today. Other forms of ...