The interplay of age, gender and amyloid on brain and cognition in mid-life and older adultsDeficits in memory are seen as a canonical sign of aging and a prodrome to dementia in older adults. However, our understanding of age-related cognition and brain morphology occurring throughout a ...
Amyloid-beta (Abeta) peptides play a key role in the pathogenesis of Alzheimer's disease and exert various toxic effects on neurons; however, relatively little is known about their influence on glial cells. Astrocytes play a pivotal role in brain homeostasis, contributing to the regulation of ...
In vitro effects of nicotine on mitochondrial respiration and superoxide anion generation In this study, we investigated the effects of nicotine on rat brain mitochondria. The polarographic studies determined the effects on the respiratory chain... Anne,Cormier,and,... - 《Brain Research》 被引量:...
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Nearly 2000 participants without contraindication to magnetic resonance imaging (MRI) were invited for brain MRI based on any of the following12: (1) prior research brain MRI as part of the cohort; (2) low cognitive scores or cognitive decline at visit 5; and (3) a random age-stratified ...
Senile plaques composed of the amyloid-β (Aβ) peptide in the brain are the core hallmarks of AD and a promising target for the development of disease-modifying therapies. However, over the past 20 years, the failures of clinical trials directed at Aβ clearance have fueled a debate as ...
- 《Behavioural Brain Research》 被引量: 130发表: 2014年 Effects of Flavonoid Compounds on β-amyloid-peptide-induced Neuronal Death in Cultured Mouse Cortical Neurons Excessive accumulation of β-amyloid peptide (Aβ) is one of the major mechanisms responsible for neuronal death in Alzheimer's ...
the insulin pathway and oxidative markers; such as lipid peroxidation, total antioxidant capacity, enzymatic antioxidant systems, the highly OS-sensitive brain creatine kinase (CK) and nuclear factor erythroid-derived 2-like 2. We evaluated whether activating AMPK had beneficial consequences on the dele...
(αβT) speeds up the formation of amyloid fibrils through the formation of unstable and temporary configurations of the αS. In this study, the most important regions that act as initiating nuclei and make unstable the initial configuration were identified based on sequence and structural ...
Jung et al., “Alzheimer's Beta-amyloid Precursor Protein Is Expressed on the Surface of Immediately Ex Vivo Brain Cells: a Flow Cytometric Study,” J... SS Jung,J Nalbantoglu,NR Cashman - 《Journal of Neuroscience Research》 被引量: 18发表: 2015年 A learning deficit related to age and...