A new study from the Center for Vital Longevity at The University of Texas at Dallas has found that the amount of amyloid plaques in a person's brain predicts the rate at which his or her cognition will decline in the next four years. The study, published inJAMA Neurology, usedpositron e...
The investigators concluded that these findings add weight to the theory that concussion and amyloid build-up in the brain are related, but that the relationship is complex, because it was not seen in the normal, non-MCI group. This has been the Medscape Neurology Minute. I'm Dr. Alan ...
A condition called amyloid angiopathy is often associated with stroke. Amyloid angiopathy is the accumulation of protein fragments in blood vessels. Typically, the presence of amyloid in the brain is associated with Alzheimer's disease, Parkinson's disease and several types of dementia.1 However, th...
On the basis of these findings, we propose that these abnormal systemic changes might not only develop secondary to brain dysfunction but might also affect AD progression, suggesting that the interactions between the brain and the periphery have a crucial role in the development and progression of ...
Now, however, Martins et al. have shown that lipids normally present in the brain can destabilize the fibrils and resolubilize them into protofibrils, which have neurotoxic effects in vitro and in vivo.doi:10.1038/ncpneuro0717NoneNature Clinical Practice Neurology...
A specific amyloid-β protein assembly in the brain impairs memory Early Warning Of Alzheimer's Poor memory function has been noted in individuals that developed Alzheimer's disease up to 15 years before the eventual diagn... S Lesné,TK Ming,L Kotilinek,... - 《Nature》 被引量: 0发表:...
Soluble amyloid-尾 in the brain Tabaton.pdfTabaton, MassimoGambetti, Pierluigi
AMYLOID PLAQUES ARE INCREASED IN THE BRAIN OF TBI SURVIVORS AT 1, 12, AND 24 MONTHS AFTER INJURY J Gatson,C Madden,J Minei,... - 《Journal of Neurotrauma》 被引量: 0发表: 2015年 AMYLOID PLAQUES ARE INCREASED IN THE BRAIN OF TBI SURVIVORS AT 1, 12, AND 24 MONTHS AFTER INJURY J ...
Intravenous administration of Nec-1 reduced the levels of Aβ plaques in the brains of aged APP/PS1 double transgenic mice. In addition, Nec-1 exhibited therapeutic effects against Aβ aggregates by inhibiting Aβ-induced brain cell death in neuronal and microglial cell lines. Nec-1 also ...
It is expressed ubiquitously, with the highest levels in the brain, heart, thyroid, adrenal and testis5 (https://www.proteinatlas.org). Reminiscent of the amyloid precursor protein APP, TMEM106B is sequentially processed through ectodomain shedding, followed by intramembrane proteolysis, with ...