Amyloid of Another Kind: The Unexpected Fat Pad Biopsydoi:10.1681/ASN.20213210S1597cMadeline KirbyVirginia Tech Carilion School of Medicine, Roanoke, VA;Douglas J. GriderVirginia Tech Carilion School of Medicine, Roanoke, VA;James S. Cain
Under the presumption that the diagnosis was AL amyloid, the patient underwent a fat pad biopsy, which was negative for amyloid. Primary amyloidosis of the kidney More results ► Dictionary browser ? ▲ Akkadian Akkerman Akko Akmola Akmolinsk Aknee Aknow akoluthos akosmism akrasia Akron Aksa ...
amyloidosis must be confirmed by histological examination of an optimal biopsy. Sites to consider for the biopsy includeabdominal wallsubcutaneous fatty tissue (fat-pad aspirate and fat-pad biopsy), vascularsubmucosaof the GI tract (minorsalivary glandsin mouth, labial soft tissue, and rectal biopsy...
Biopsy specimens are collected either in the form of fat pad aspirate or as formalin fixed paraffin embedded (FFPE) tissues [30]. The presence of amyloid proteins that form well-ordered fibril structures can be detected by positive staining with Congo red dye [31, 32]. Presence of Serum ...
42 Biopsy of other tissues, such as rectum, labial salivary gland, and subcutaneous fat pad, has been reported to have a similar sensitivity and can also be examined. Skin biopsy is useful in evaluating small-fiber neuropathy but has not been shown to be sensitive or specific fo...
Extracardiac tissue biopsies (such as abdominal fat pad aspirate) have varying and unreliable sensitivity [38]. Tissue samples from orthopedic procedures, such as carpal tunnel syndrome surgery, have unclear diagnostic reliability at this time but may be useful. Traditionally, endomyocardial biopsy has...
Two of the four abdominal fat aspirates were positive for amyloid. Attention to the morphology of cells accompanying amyloid allows exclusion of medullary thyroid carcinoma, thereby avoiding unnecessary surgery. Moreover, aspirates from the abdominal pad of fat and the thyroid and salivary glands, ...
Bone marrow (BM) biopsy, in conjunction with fat pad aspiration/biopsy, is often the first step in patients with suspected amyloidosis. Although BM involvement by AL amyloid has been previously characterized, little is known about the incidence, morphology and clinical phenotype of non-AL amyloid ...
An abdominal fat pad core needle biopsy (CNB) is the diagnostic gold standard for secondary amyloidosis. Although CNB is useful to detect amyloid infiltration of a specific organ, fine-needle aspiration (FNA) is proven to be the best diagnostic method for thyroid disorders. Guidelines recommend ...
Because biopsy specimens were considerably smaller than the cardiac tissue samples (30–150 mg versus 1–5 g), we downsized the amyloid extraction protocol accordingly. Otherwise, the procedure remained as previously described (3). The extraction from fat pad biopsies produced a very limited amount...