Liberski, P.P., Yanagihara, R., Brown, P., Kordek, R., Kloszewska, I., Bratosiewicz, J., Gajdusek, D.C., 1996. Microwave treatment enhances the immunostaining of amyloid deposits in both the transmissible and non-transmissible brain amyloidoses. Neurodegeneration 5, 95-99....
Abraham CR, Potter H (1989) Alzheimer’s disease: recent advances in understanding the brain amyloid deposits. Bio/Technol 7:147–153Abraham CR , Potter H ( 1989 ): Alzheimer's disease: Recent advances in understanding the brain amyloid deposits . Biotechnology 7 : 147 – 153 ....
通常还会产生其他次要的aβ肽,如β-淀粉状肽1-34、1-37、1-38和1-39,很少有报告量化了这些肽在大脑中的水平。 Beta-amyloid is the main component of amyloid deposits in the AD brain. Beta-amyloid peptides have a heterogeneous C-terminus with the majority composed ofAβ1-40, while a minor pr...
Brain InjuriesAniline CompoundsThiazolesFemaleMaleAmyloid beta-PeptidesComment on JAMA Neurol. 2014 Jan;71(1):23-31.doi:10.1038/nrneurol.2013.250Hemi, MalkkiNat Rev NeurolNature Reviews NeurologyMalkki H (2014) Traumatic brain injury: PET imaging detects amyloid deposits after TBI. Nat Rev Neurol...
Of importance was the finding that IHC staining of pyroGlu-3 Aβ was sensitive for fixation time due to a lack of diffuse pyroGlu-3 Aβ deposits in long-term fixed vervet brain. There, pyroGlu-3 Aβ IR (Figure 2F) was only noted in a subset of R1282-positive plaques (Figure 2C)...
4, with the most advanced Braak stage [2, 3], MALDI-IMS analysis identified distinct deposits of Aβ1– 40 and Aβ1–42 in the AD brain tissue (Fig. 1A, B). The Table 1 Clinical and pathological data of AD with CAA cases and aged SP O subjects Subject No. Gender Age at death...
In this paper Virchow described the small round deposits in the nervous system (Figure 1) with the mention that those structures showed the same color reaction with iodine and sulfuric acid, i.e. a change from brown to blue, typical to starch. Therefore, Virchow was convinced that those ...
New research from the University of Chicago points to microglia, key immune cells in the brain, as a key mediator in the relationship between the gut microbiome and b-amyloid deposits in male mice in a model of Alzheimer's disease. The results, published on December 2 in theJournal of Expe...
Hereditary cystatin C amyloid angiopathy is a dominantly inherited disease caused by a leucine to glutamine variant of human cystatin C (hCC). L68Q-hCC forms amyloid deposits in brain arteries associated with micro-infarcts, leading ultimately to paralysis, dementia and death in young adults. To ...
The same peptide that forms amyloid deposits in AD brain was also found in a soluble form (sAβ) normally circulating in the human body fluids (Seubert et al., 1992 and Shoji et al., 1992). Zlokovic et al. (1994), reported that the blood-brain barrier (BBB) has the capability to ...