et al. The tumor suppressor FLCN mediates an alternate mTOR pathway to regulate browning of adipose tissue. Genes Dev. 30, 2551–2564 (2016). 134. Ljubicic, V. & Jasmin, B. J. AMP-activated protein kinase at the nexus of therapeutic skeletal muscle plasticity in Duchenne muscular dystrophy...
133. Wada, S. et al. The tumor suppressor FLCN mediates an alternate mTOR pathway to regulate browning of adipose tissue. Genes Dev. 30, 2551–2564 (2016). 134. Ljubicic, V. & Jasmin, B. J. AMP-activated protein kinase at the nexus of therapeutic skeletal muscle plasticity in Duchenne ...
在氧化应激下,PKM2 易位至线粒体,并通过磷酸化 Bcl2 直接调节细胞凋亡。此外,PKM2 缺乏会限制内皮细胞生长并触发各种细胞类型的先天免疫信号转导。 2024年2月6日,华南农业大学陈金顶和范双旗团队在Journal of Virology杂志上在线发表题为 “PKM2 induces mitophagy through the AMPK-mTOR pathway promoting CSFV proli...
133. Wada, S. et al. The tumor suppressor FLCN mediates an alternate mTOR pathway to regulate browning of adipose tissue. Genes Dev. 30, 2551–2564 (2016). 134. Ljubicic, V. & Jasmin, B. J. AMP-activated protein kinase at the nexus of thera...
AMPK信号通路与mTOR通路存在交叉 来自“The AMP-activated protein kinase (AMPK) signaling pathway coordinates cell growth, autophagy, & metabolism” 在营养缺乏的情况下,AMPK是抑制细胞生长的代谢检查点。这一机制是通过抑制mTORC1通路实现的。AMPK可以直接磷酸化Raptor,阻断mTORC1激酶复合物磷酸化其底物的能力。当然...
2024年2月6日,华南农业大学陈金顶和范双旗团队在Journal of Virology杂志上在线发表题为“PKM2 induces mitophagy through the AMPK-mTOR pathway promoting CSFV proliferation”的研究论文。 在这项研究中,作者研究了宿主细胞蛋白PKM2调节线粒体自噬以响应CSFV感染的机制。结果表明,CSFV通过PKM2调节细胞内丙酮酸含量,PKM2...
AMPK/mTOR pathway significance in healthy liver and non‐alcoholic fatty liver disease and its progressionAMPK/mTOR pathwayautophagylipid metabolismnon-alcoholic fatty liver diseaseobesity.Obesity is related to several organs, but the liver is particularly affected. Adenosine monophosphate-activated protein ...
2024年2月6日,华南农业大学陈金顶和范双旗团队在Journal of Virology杂志上在线发表题为“PKM2 induces mitophagy through the AMPK-mTOR pathway promoting CSFV proliferation”的研究论文。 在这项研究中,作者研究了宿主细胞蛋白PKM2调节线粒体自噬以响应CSFV感染的机制。结果表明,CSFV通过PKM2调节细胞内丙酮酸含量,PKM2...
7. Park, K.K. et al. Promoting axon regeneration in the adult CNS by modulation of the PTEN/mTOR pathway.Science322, 963-966 (2008). 8. Abe, N., Borson, S.H., Gambello, M.J., Wang, F. & Cavalli, V. Mammalian target of rapamycin (mTOR) activation increases axonal growth cap...
近年来,许多证据表明顺铂介导的AMP活化蛋白激酶(AMPK)通过哺乳动物雷帕霉素靶标(mTOR)参与食管癌细胞的凋亡[6-7]。同时,顺铂通过与冬凌草甲素等药物联合治疗,可抑制mTOR的表达从而增强细胞毒性和细胞凋亡作用[8]。然而,顺铂和虫草素在...