Viollet B, Horman S, Leclerc J, Lantier L, Foretz M, Billaud M, et al. AMPK inhibition in health and disease. Crit Rev Biochem Mol Biol. 2010;45(4):276-95.Viollet B, Horman S, Leclerc J, Lantier L, Foretz M, Billaud M, Giri S, Andreelli F. AMPK inhibition in health and ...
AMPK signalling in health and disease In eukaryotic cells AMP-activated protein kinase (AMPK) plays a major role in regulating cellular energy balance. AMPK responds to changes in intracellular adenine nucleotide levels, being activated by an increase in AMP/ADP relative to ... Carling,David - 《...
One of the many important cellular control systems is the AMP-activated protein kinase (AMPK), which is the putative metabolic or energy sensor of the cell. AMPK signaling appears to have broad implications in cardiovascular health and disease. This review will focus on AMPK's emerging role as ...
The primary mechanism for detecting and responding to changes in energy state is through the 5' adenosine monophosphate-activated protein kinase (AMPK) pathway. As might be expected from its role, AMPK effects are pleiotropic, impacting multiple pathways in order to spare and/or generate ATP. The...
AMPK signaling appears to have broad implications in cardiovascular health and disease. This review will focus on AMPK's emerging role as an integrating metabolic sensor in the cardiovascular sys- tem. The discovery of AMPK is not recent. Its existence was uncovered by two independent observations ...
[8] Kreuz, S., & Fischle, W. (2016). Oxidative stress signaling to chromatin in health and disease. Epigenomics, 8(6), 843–862. https://doi.org/10.2217/epi-2016-0002
31. Carling, D. AMPK signalling in health and disease. Curr. Opin. Cell Biol. 45, 31–37 (2017). 32. Stapleton, D. et al. Mammalian AMP-activated protein kinase subfamily. J. Biol. Chem. 271, 611–614 (1996). 33. Thornton, C., Snowden, M. A. & Carling, D. Identification of...
Age-Induced Alterations in Hippocampal Function and Metabolism As the nervous system ages, a variety of changes occur in metabolism supporting glial and neuronal function, resulting in greater susceptibility to disease... PK Shetty,F Galeffi,DA Turner - 《Aging & Disease》 被引量: 49发表: 2011年...
AMPK in health and disease Under normal conditions, AMPK and mTOR activity is coordinated to maintain homeostasis and good health. When signaling between these two enzymes becomes out of balance, problems can arise, as illustrated by over-activation of mTOR signaling in obesity, metabolic syndrome,...
The health benefits of dietary fiber: Beyond the usual suspects of type 2 diabetes mellitus, cardiovascular disease and colon cancer Dietary fiber (DF) is deemed to be a key component in healthy eating. DF is not a static collection of undigestible plant materials that pass untouched or ......