It remains to be seen if combination of newly identified drugs with traditional renoprotective medicine will have any synergistic therapeutic benefits without adding to side effects.doi:10.1016/j.lfs.2020.118828Zhuo Li aJia Li bXiao Miao cWenpeng Cui a...
This study comprehensively reviews AgNP-based wound dressing applications across different wound types, identifying and discussing the associated benefits and complications, aiming to bridge identified knowledge gaps.Drawing upon available resources, we assembled and reviewed the applicable literature.Suitable ...
Third, we analyze possible anti-fibrosis mechanisms and other benefits of AMPK on the liver. Finally, we summarize and briefly explain the current objections to targeting AMPK. This review may aid clinical and basic research on AMPK, which may be a novel drug candidate for hepatic fibrosis. ...
In summary, AMPK activation has favorable effects on energy metabolism disorders in the brain, but many aspects of its benefits and disadvantages need to be verified. 3.2. AMPK and Aβ Aβ is a peptide composed of 39–43 amino acids (molecular weight 9.0 and 13.5 kDa) and is the main ...
Mitoxantrone has been approved by the FDA for worsening relapsing remitting and secondary progressive Multiple Sclerosis. However the benefits of this agen... J Ramtahal,A Jacob,K Das,... - 《Journal of Neurology》 被引量: 179发表: 2006年 Modulatory effects of melatonin and vitamin E on doxo...
after CR, can alone activate AMPK in mice, nematodes and flies1. AMPK is also required for LCA to effect rejuvenation of muscle in aged mice, and extension of lifespan and healthspan in nematodes, flies and mice1. However, how AMPK is activated by LCA to produce these benefits is unknown...
109,110 It would also be interesting to explore other benefits of the AMPK-PDZD8-GLS1 axis in mediating the extension of lifespan and healthspan by calorie restriction. Together, our study reveals an AMPK-PDZD8-GLS1 axis that transmits low glucose-activated AMPK activity to phosphorylation of...
side effects of traditional treatments and decreases drug resistance, providing a safer and more patient-friendly alternative. These benefits are crucial in the field of medicine, where personalized and targeted therapies are essential for optimizing patient care and improving overall health outcomes. In...
AMPK is also required for LCA to effect rejuvenation of muscle in aged mice, and extension of lifespan and healthspan in nematodes, flies and mice1. However, how AMPK is activated by LCA to produce these benefits is unknown. AMPK can be activated in multiple ways depending on the severity ...
Premature ovarian failure (POF) caused by chemotherapy is a growing concern for female reproductive health. The use of metformin (MET), which has anti-oxidative and anti-inflammatory effects, in the treatment of POF damaged by chemotherapy drugs remains