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Additionally, BMS-477118 prevented DSS-induced weight loss and enhanced tight junction proteins. These effects, in conjunction with reduced oxidative stress and its potential anti-inflammatory, antiapoptotic, and autophagy-inducing properties, fostered prolonged survival in rats with c...
Cancer is one of the major causes of death worldwide. There are several manifestations of this deadly disease, such as lumps, unusual bleeding, protracted coughing, weight loss, and decreased appetite [1,2,3]. Factors effective in causing cancer include smoking, obesity, an unhealthy diet, exc...
Curcumin prevented partially the weight loss in db/db mice, increased AMPK and PPARγ expression and diminished NF-κB protein in db/db mice, but did not alter the SIRT1 expression. Curcumin regulates AMPK, PPARγ and NF-κB expression, but not of SIRT1. 展开 ...
We showed that HFD-fed female mice were protected from insulin resistance and hepatic steatosis compared to males, despite similar body weight gains. Females were particularly protected from renal dysfunction, oxidative stress, and tubular lipid accumulation. Both HFD-fed male and female mice presented...
The experiments demonstrated that chicoric acid significantly enhances glucose uptake in insulin-sensitive and insulin-resistant cells. This effect was primarily mediated through the activation of AMPKα, a key metabolic regulator that responds to energy stress. The phosphorylation of AMPKα triggered downs...
1 and 3. (a) Body weight in grams of female trained mice (6 weeks of age, n=5-11/group) from control and trained (wheel) groups. Relates to Fig. 1a and b. (b) Body weight in grams of sedentary and trained (treadmill) at the end of the protocol for 12 -weeks-old (n=10 ...
AMPK Metabolic Activator is our customer-favorite formula for weight management. It contains 450 mg ofG. pentaphyllum(Jiaogulan) extract and 500 mg of hesperidin, a flavonoid derived from citrus fruit. Each bottle contains 30 vegetarian tablets, enough for a one-month supply at the suggested dosi...
Conversely, delivery to the VMH in euthyroid rats of adenovirus encoding a dominant negative mutant of AMPK-α1 had the opposite effects, causing weight loss and increased expression of brown fat thermogenic markers, both effects being reversed by the β3-adrenoceptor antagonist. These results ...