In Escherichia coli from the German food production chain, the majority of AmpC beta-lactamase activity can be attributed to plasmid-mediated CMY-2 or overproduction of chromosomal AmpC beta-lactamase, but occasionally other enzymes like DHA-1 are involved. This study investigated the prevalence of...
Background: AmpC beta-lactamases confer resistance to oxyimino cephalosporins and cephamycins and are not inhibited by the beta-lactamase inhibitors such as clavulanic acid. The genes encoding AmpC beta-lactamases occur naturally on the chromosome of several members of the Enterobactericeae . Since...
Inhibition of AmpC beta-lactamase through a destabilizing interaction in the active site. Biochemistry. 2001; 40 :7992–9.Trehan I, Beadle BM, Shoichet BK. Inhibition of AmpC beta- lactamase through a destabilizing interaction in the active site. Biochemistry 2001;40:7992-7999....
This study determined the presence of Amp C beta lactamase producing Pseudomonas aeruginosa among the seventy four uropathogens studied using standard techniques. Results obtained revealed that the studied isolates show an alarming rate of resistance to the extended spectrum beta lactam antibiotics and the...
The problem of resistance to beta-lactam antibiotics, which is caused by ESBL and AmpC β-lactamases, is getting worse globally. Infections caused by bacterial isolates harboring these enzymes are difficult to treat with carbapenems being the sole effect
In the recent years, multidrug resistant (MDR) neonatal septicemia-causing Enterobacterales has been dramatically increased due to the extended-spectrum beta-lactamases (ESBLs) and AmpC enzymes. This study aimed to assess the antibiotic resistance pattern, prevalence of ESBLs/AmpC beta-lactamase genes...
Objective To purify AmpC beta-lactamase from Enterobacter cloacae and study its physical and chemical characteristics.Methods The bacteria were fragmentized by ultrasonication and AmpC beta-lactamase was purified by ion-exchange.The properties of the purified enzyme,such as molecular weight and isoelectri...
AmpC β-lactamase is a bacterial enzyme with great clinical impact as it mediates β-lactam antibiotic resistance in many Gram-negative bacteria. To facilitate the structure–function relationship studies on this clinically important enzyme, we developed new strategies for production of recombinant -tagg...
Detection of FOX-AmpC-β-lactamase gene and antibiogram of AmpC-beta-lactamase-producing pathogens isolated from chronic suppurative otitis media patients in NigeriaAmadi, Ibiam FrancisNchedo, Obasikene CatherineObaji, Ariom ThaddaeusAgbonifo, Monday...
AmpC beta-lactamase is a cephalosporinase, which exhibits resistance against all existing beta-lactam antibiotics except carbapenems. Their occurrence in many bacterial pathogens poses a threat to public health and is a growing concern in the medical world. The ampC gene is highly inducible in ...