AmpC beta-lactamase is a cephalosporinase, which exhibits resistance against all existing beta-lactam antibiotics except carbapenems. Their occurrence in many bacterial pathogens poses a threat to public health and is a growing concern in the medical world. The ampC gene is highly inducible in ...
Inhibition of AmpC beta-lactamase through a destabilizing interaction in the active site. Biochemistry 2001;40:7992-9. [PubMed: 11434768]Trehan I, Beadle BM, Shoichet BK. 2001. Inhibition of AmpC β-lactamase through a destabilizing interaction in the active site . Biochemistry 40 :7992–...
Background: AmpC beta-lactamases confer resistance to oxyimino cephalosporins and cephamycins and are not inhibited by the beta-lactamase inhibitors such as clavulanic acid. The genes encoding AmpC beta-lactamases occur naturally on the chromosome of several members of the Enterobactericeae . Since...
beta-lactamases are the most widespread resistance mechanisms to beta-lactam antibiotics, and there is a pressing need for novel, non-beta-lactam drugs. A database of over 200,000 compounds was docked to the active site of AmpC beta-lactamase to identify potential inhibitors. Fifty-six compound...
In competition assays for radiolabeled penicillin, penicillin-binding proteins (PBPs) 4, 7a, and 7b showed very high affinities for strong inducers of AmpC beta-lactamase. Loss of PBP 4 resulted in diminished inducibility. This suggests that if PBPs are involved in induction of AmpC beta-lacta...
AmpC beta-lactamase-producingE. coliandKlebsiellain livestock, poultry, and human contacts, and to investigate the genetic relatedness of the recovered isolates. In total, 140 samples were collected, including human fecal samples (n = 20) of workers with intimate livestock contact, cattle rectal ...
Burden of different beta-lactamase classes among clinical isolates of AmpC-producing Pseudomonas aeruginosa in burn patients: A prospective study Background: Pseudomonas aeruginosa is one of the most common pathogens causing infections in burns, and shows increasing resistance to 尾-lactam antibiotic......
AmpC, a class C ²-lactamase, is a main cause of antibiotic resistance to cephalosporins in many species of bacteria. Although a mechanism involving acylation by S64 followed by hydrolytic cleavage has been generally accepted, the exact roles that some active site residues play in recognitio...
CONCLUSIONS: Domestically acquired ceftriaxone-resistant Salmonella has emerged in the United States. Most ceftriaxone-resistant Salmonella isolates had similar AmpC plasmid-mediated resistance. 展开 关键词: antibacterial agents bacterial diseases beta-lactamase ceftriaxone cephalosporins disease surveys drug ...
outbreak of meropenem-resistant serratia marcescens comediated by chromosomal ampc -lactamase overproduction and outer membrane protein loss B Suh,K Bae,J Kim,... 被引量: 0发表: 2019年 Novel carbapenem-hydrolyzing beta-lactamase, KPC-1, from a carbapenem-resistant strain of Klebsiella pneumoniae....