Our hypothesis was that highly sensitive detection of disease burden prior to allo-SCT could offer improved prediction of both relapse and survival. Traditional response criteria based on BM examination could risk-stratify these 74 patients into two groups: the ‘CR’ group (n=48) with a 3-year...
However, while high diagnostic copy numbers of both genes associated with shorter event free survival (EFS) and overall survival (OS) in patients receiving chemotherapy, there was no prognostic impact in patients undergoing HSCT. Our data suggests that the adverse prognostic impact of high BAALC ...
Acute myeloid leukemia (AML) is a highly heterogeneous hematopoietic malignancy characterized by excessive proliferation and accumulation of immature myeloid blasts in the bone marrow. AML has a very poor 5-year survival rate of just 16% in the UK; hence