Germline genetic polymorphisms are associated with disease-free survival in adults with acute myeloid leukemia (AML): A genomewide association study from the PGRN-riken global allianceSook Wah Yee, PhD
Evidence that allo-HCT can deliver long-term survival in a significant proportion of patients with PREF AML has been accumulating over the last decade and represents an important advance in the management of this sizeable patient popula- tion for whom no other effective therapy exists (Craddock et...
Moreover, survival rates in adults are quite poor and remain virtually unchanged over the last decade.1 The molecular genetics of AML has been extensively studied. AML with normal cytogenetics accounts for ~ 50% of all AML, and this subtype of AML is notable for recurrent mutations in ...
in patients with newly diagnosedFLT3-mutated (ITD or TKD) AML aged 18–59 years [24]. Of the 713 patients who enrolled in RATIFY, 23% hadFLT3-TKD mutations and 77% hadFLT3-ITD mutations. At the median follow-up of 59 months, the median overall survival (OS) favored midostaurin with 7...
(Ediriwickrema et al.2023). Researchers into primitive stem cell signatures has shown a correation with poor survival and differentiated AML cells may influence the immune system (Galen et al.2019). It is now evident that different types of AML respond differently to new treatments, such as ...
They found that MRD+ patients who achieved CR1 had significantly worse overall survival (50% vs. 65%, P < 0.001) and relapse-free survival (38% vs. 58%, P < 0.001) compared to MRD- patients, mainly due to a higher relapse rate (54% vs. 32%, P < 0.001). Multivariable analysis ...
We still have a long way to further improve the survival of the AML patients, thus many investigational drugs have been explored to target the primary and secondary treatment resistance in AML patients. This review will provide updates of the emerging therapeutic approaches for the treatment of ...
When compared to vehicle controls, a significant (p < 0.05) increase in survival was observed at both doses with a 10% or 20% cure rate at the low and high doses, respectively (Figure 4B). Monitoring of CT53518 levels determined that the average nadir plasma concentration (66 nM) may...
31,32 The intensity of an allo-HCT preparative regimen has been shown to affect survival in AML; whenever possible, MAC is preferred over reduced-intensity conditioning regimens,33 particularly in those with evidence of MRD positivity before allo-HCT.18,34 However, in many patients with AML, ...
[5,6]. Over the past decades, increasing numbers of multidrug combinations in cancer therapy and improved long-term survival in cancer patients have led to an increasing incidence of t-AML [1,7,8,9,10]. Owing to its secondary nature, t-AML is frequently associated with molecular ...