Indeed the prevalence of ARMs has been blamed for the housing bubble in the mid-2000s and the subsequent recession. See also: Credit Crunch, Teaser Rate. Anti-Money Laundering Any law or regulation requiring an institution to perform due diligence on potential clients to ensure that it is not...
In general, AML prognosis is broadly stratified based on patient age. Patients 60 years old or younger have a 35–40 % chance of achieving a cure while those older than 60 have only a 5–15 % chance [2]. Yet, AML prevalence is much more common among the elderly with a median age ...
Human myeloid leukemia cell lines (Kasumi-1, K562, HEL, NB4, KG-1, MOLM-13, MV4-11, HL-60, and THP-1), 32Dcl3 murine myeloid cell line, and HEK293T cells were routinely cultured in our laboratory. Myeloid leukemia cells were maintained in RPMI-1640 medium (Corning, NY, USA) supp...
cytopenia are predictive of hematopoietic malignancy development and thus, accelerate the progression to hematological neoplasm; myelodysplastic syndrome (MDS) and MDS/AML.TP53-mutated CH occurs in about 2–6% of cancer patients.TP53-mutated MDS and AML account for up to 13% of all de novo cases....
et al. Prevalence and prognostic significance of Flt3 internal tandem duplication in pediatric acute myeloid leukemia. Blood 97, 89–94 (2001). Article CAS PubMed Google Scholar Korshunov, V. A. Axl-dependent signalling: a clinical update. Clin. Sci. 122, 361–368 (2012). Article CAS ...
Mutations in isocitrate dehydrogenase 1 and 2 (IDH1/2) genes occur in about 20% patients with acute myeloid leukemia (AML), leading to DNA hypermethylation and epigenetic deregulation. We assessed the prognostic significance of IDH1/2 mutations (IDH1/2+)
The analysis of 4 MDS, 23 AML and 11 CML patients from Yugoslavia revealed theprevalence of the N-ras mutation (83%) over K-ras mutations (17%). Although the frequencies of the N- and K-ras mutations in these patients were similar to the ones reported for patients from USA and Japan...
Given the prevalence of NAFLD and NASH, and the high risk of progression into cirrhosis and hepatocellular carcinoma from NASH, inhibiting hepatocytes’ injury and the progression of simple steatosis to NASH is of great clinical value and impact. Saturated fatty acids, especially LSFAs can trigger ...
Estimations of the increasing prevalence and plateau prevalence of chronic myeloid leukemia in the era of tyrosine kinase inhibitor therapy. Cancer 118, 3123–3127 (2012). PubMed Google Scholar Papaemmanuil, E. et al. Genomic classification and prognosis in acute myeloid leukemia. N. Engl. J....
Acute myeloid leukemia (AML) is a heterogeneous disease with dismal response warranting the need for enhancing our understanding of AML biology. One prognostic feature associated with inferior response is the presence of activating mutations in FMS-like