出处 《赣南医学院学报》 2016年第2期208-211,共4页 JOURNAL OF GANNAN MEDICAL UNIVERSITY 基金 江西省卫生计生委科技计划资助项目(编号:20155410) 关键词 突变基因 急性髓系白血病 发生率 中国 mutation gene acute myeloid leukemia incidence China 分类号 Q754 [生物学—分子生物学] 登录...
incidences of acute and chronic graft-versus-host disease (GVHD) among evaluable patients were 4.3% (2/26) and 23.9% (11/46) respectively.After a median follow-up of 8 months for survivors,the treatment-related mortality was 23.9% (11/46).The 30-month disease-free survival (DFS) rate...
Incidence and prognostic influence of DNMT3A mutations in acute myeloid leukemia. J Clin Oncol 2011; 29: 2889–96. • Ferrara F, Criscuolo C, Riccardi C, et al. FLT3 mutations have no prognostic impact in elderly patients with acute myeloid leukemia and normal karyotype. Am J Hematol 2009...
inat ion a n d prognosis of disease were a n alyzed.The results showed t hat the c—kit mutation was found in 14 out of 31 AM Dat ients and the mutation f requency was 45.16% .M ale patients had a higher incidence of c.kit mutat ion than t hat of female patients(P=0.020)....
临床儿科杂志第28卷第5期2010年5月JClinPediatrVol.28No.5May. 010在儿童急性淋巴细胞白血病(ALL)中,t(1 ;21)染色体结构异常较为常见,发生率约为20%。该易位导致12p13的TEL基因与 1q 上的AML基因融合,形成TEL-AML1融合基因。白血病相关融合基因的研究作为白血病特异性分子标志物之一,对了解白血病的发病机制,及...
John Leonard, MD:Interesting. Well, it’s good to see progress there. Like in so many other areas, once you have one successful drug with the midostaurin story, then everybody else is going there and then it’s, how can we carve out other areas, make it a little better, etc? But ...
The standard treatment for most acute myeloid leukemia (AML) is chemotherapy, which is often associated with severe adverse effects. One strategy to reduce the adverse effects is targeted therapy that can selectively deliver anticancer drugs to tumor cel
in Annexin-FITC-stained cells, but detected a decrease in S-phase population in EZH1-depleted cells (Supplementary Fig.1h). To determine this effect in vivo, we subcutaneously injected EZH1-depleted SKNO-1 cells (0.3 × 106) into the flanks of nude mice. Although tumor incidence was...
Abstract To study the incidence,the types of fusion genes and the clinical significance of rearrangements of mixed lineage leukemia (MLL) gene in acute leukemia (AL), the rearrangements of MLL gene of 60 patients with AL were detected by fluorescence in situ hybridization (FISH) and 6 types of...
Incidence and prognostic influence of DNMT3A mutations in acute myeloid leukemia. J Clin Oncol 2011; 29: 2889–96. • Ferrara F, Criscuolo C, Riccardi C, et al. FLT3 mutations have no prognostic impact in elderly patients with acute myeloid leukemia and normal karyotype. Am J Hematol 2009...