Shen and colleagues on the relationship of gene mutation in the pathogenesis of acute myeloid leukemia (AML). He states that the study shows that DNA methyltransferase 3 alpha (DNMT3A) and myeloid/lymphoid leukemia (MLL) contribute to poor prognosis of AML. He argues that the study does not ...
A subset of cases of AML with biallelic mutation of CEBPA have an abnormal karyotype. 【翻译】部分急性髓系白血病伴双等位CEBPA突变病例具有异常核型。 Similarly to in AML with mutated NPM1, del(9q) is common among this group and do...
The favourable prognosis associated with CEBPA mutation in AML is now known to be related to biallelic mutations only; therefore, biallelic mutation is now required for assignment to this category. The biallelic mutation is associated with a specific gene expression profile that is not associated with...
AML伴NPM1主要有两组免疫表型,一组是幼稚髓系的免疫表型谱,另一组是单核系免疫表型谱(CD36+,CD64+,CD14+)。 CD34 is negative in most cases but CD34+ cases do occur and have been associated with an adverse prognosis. A very small...
DOX的原发性与继发性耐药产生的分子机制有许多种,目前尚无定论,耐药性分子机制涉及多耐药基因-1(multidrugresistancegene1,MDR-1)编码的P-糖蛋白(P-gp)的过度表达、NF-kB、PI3K/Akt、STAT3、JNK等信号通路[9,10,,1,12,13,14]。在人类基因组测序计划陆续完成后,生命科学进入一个前所未有的新时代,在人类...
9. Lyu M, Liao H, Shuai X et al. The prognosis predictive value of FMS-like tyrosine kinase 3-internal tandem duplications mutant allelic ratio (FLT3-ITD MR) in patients with acute myeloid leukemia detected by GeneScan. Gene 2020;726:144195. ...
综述·WT1基因在AML中的意义 王晓亮，李丽梅 急性髓细胞白血病（AML）是源于造血干/祖细胞的恶性克隆性疾病，其发生发展过程中常伴多种染色体和基因异常，且与发病机制、疾病诊断、预后密切相关。然而，除基因突变外，转录后和翻译水平的修饰在AML 的发病中也发挥着重要作用。肾母细胞瘤基因1（Wilm's tumor gene1，...
Thirty percent of acute myeloid leukemia (AML) patients with poor prognosis harbor FLT3 gene mutations. Compared to other AML patients, they have a higher risk of relapse and shorter overall survival (OS) and disease-free survival (DFS). Despite this, effective treatment strategies are lacking. ...
HCT is never indicated in patients in CR1, except for the small fraction of patients with per- sistent RQ-PCR positivity of PML-RARA after consolidation (<1%), given the poor prognosis associated with this subset. HCT is also indicated in APL patients who relapse and achieve second or ...
Overall, AML with germline CEBPA mutation has a favourable prognosis. 【翻译】总的来说,急性髓系白血病伴胚系CEBPA突变的预后良好。 In one series, the 10―year overall survival rate was 67%, although multiple relapses were reported. 【翻...