Between 1977–87, 319 patients with AML were admitted to Hannover Medical School. At all 41 of these patients were not treated (median duration of survival 0.6 months). Among the 278 treated patients, there was a CR rate of 53.6% the median duration of remission was 10.1 months and the ...
However, studies of this AML subtype have been hampered by the few number of patients reported, frequently collectively considered with those with AML carrying the t(8;21) translocation. We performed a retrospective study in 110 patients with inv(16)/t(16;16) AML (median age, 34 years) ...
Multivariate analysis showed the proportion of bone marrow blasts ≥65.4% was a factor significantly affecting OS in PTPN11 mut patients (p = 0.043). Keywords: acute myeloid leukemia; PTPN11 mutations; prevalence; clinical characteristics; prognosis 1 Introduction Acute myeloid leukemia (AML) is a ...
It has also been reported to be functionally expressed by myeloid cells, but expression and function on malignant cells of the myeloid lineage have not been studied so far. Here we analyzed expression of DNAM-1 in leukemic cells of acute myeloid leukemia (AML) patients. We found substantial ...
(e.g., AML, ALL, CML, CLL), and lymphomas are not exceptions [13,14,15,16,17,18]. Inhibition of p53 and the mutant forms are associated with leukemia resistance to treatments and poor prognosis [19,20]. Additionally, mutation or deletion inTP53might cause progression in leukemia via ...
This retrospective study assessed the prognostic factors associated with early and long-term outcome in consecutive patients with acute myeloid leukaemia (AML) admitted to the intensive care unit (ICU) over a 9-year period. A total of 83 patients were studied (age 48 +/- 16 years), among wh...
Molecular Pathogenesis of Follicular Lymphoma: A Cross Talk of Genetic and Immunologic Factors Follicular lymphoma (FL) is the second most frequent type of non-Hodgkin's lymphoma in adults. The disease is characterized by an indolent course with freq... DD Jong - 《Journal of Clinical Oncology》...
Acute myeloid leukaemia (AML) is the most frequent acute leukaemia in adults with an incidence of 3–5 cases per 100,000 population per year [1]. AML is highly heterogeneous with more than 250 different mutations and 20 cytogenetic alterations identified [2]. Despite that, the therapeutic appr...
It was shown that inhibiting some LncRNAs that are involved in AML resistance could reduce the resistance of AML cells (Izadirad et al., 2021). Another study illustrated that lncRNA-AC026150.8 exhibited upregulated expression in AML patients, which was associated with poor prognosis, high ...
The Treatment of Acute Myelogenous Leukemia in Children and Adults: VAPA Update Major progress in the treatment of acute myelogenous leukemia (AML) has occurred during the past decade. Advances in chemotherapy and supportive care have ... HJ Weinstein,RJ Mayer,DS Rosenthal,... - Springer Berlin...