In acute situations with stable patients, a 150-mg intravenous bolus is followed by a 1.0-mg/min infusion for 6 hours and then 0.5 mg/min thereafter. In cardiopulmonary resuscitation (CPR), a 300-mg intravenous bolus is given and repeated with multiple boluses as needed ifdefibrillationis...
300mg IV/IO push → (if no conversion) 150 mg IV/IO push →(after conversion)Infusion #1 360 mg IV over 6 hours (1mg/min) → Infusion #2 540 mg IV over 18 hours (0.5mg/min) For tachyarrhythmias that are not life-threatening, consider expert consultation before use. ...
OBJECTIVE: To compare continuous diltiazem infusion (DILZ; group 1), amiodaron (AMIO) as a single IV bolus dose (group 2) and AMIO continuous infusion (group 3) on acute and 24 hour heart rate (HR) control in AFIB/AFLU or AT. METHODS: 30 sedated and ventilated pts (age 64...
The recommended dose of amiodarone in this context is a 150 mg bolus, followed by an infusion of 1 mg/min for 6 h, then 0.5 mg/min for 18 h [20]. To pharmacologically terminate a hemodynamically tolerated VT, the ESC recommends either IV amiodarone or procainamide, while the American Co...
Monitor initial rate of infusion closely; do not exceed recommended rate.Use volumetric infusion pump. Do not use drop-counter infusion sets; may result in underdosage.DosageAvailable as amiodarone hydrochloride; dosage expressed in terms of the salt.Pediatric...
Transient overshoots over steady state responses (a) and initial prodrug accumulation over steady state levels (b) could be related to the application of prodrug as a 37X bolus in this particular study. Measurements below the level of quantitation (BLOQ, panel b) are shown at the appropriate ...
additional bolus of 1.5～3 mg/kg could be repeated every other 15～30 min.Results: The success rate,defined as disappearance of the arrhythmia,was 85.7%.The rate of amiodarone on the termination episodes of ventricular tachycardial was 25%.There were no significant changes in the PR,QRS,QTc...
Twenty-four patients in this group received intravenous amiodarone for treatment of postesophagectomy atrial fibrillation. † Hypotension requiring treatment with fluid bolus or vasopressors. ‡ Bradycardia was defined as heart rate <50 bpm and/or requiring treatment. Ten patients in the amiodarone pr...
In our series of 107 patients with potentially lethal ventricular arrhythmias, amiodarone was administered as a 5-mg/kg bolus infusion, followed by 600–800 mg/day for 7–10 days. A mean daily maintenance dose of 270 mg/day was given for an average of 15 months (range <57). Pro...
A more gradual intravenous administration of amioda- rone may have avoided the acute hypotension seen with bolus administration, but presumably it would not avoid the exacerbation of left ventricular failure which occurred in three patients receiving a constant intravenous infusion. De- spite the ...