The vesicular GABA transporter differs from the two VMATs by belonging to a different class, having 10 rather than 12 transmembrane domains. The vesicular GABA transporter shares with the VMATs, however, a lack of substrate specificity, and will transport the inhibitory transmitter glycine as well...
(class I). Of 267 patients who were homozygous for the ΔF508 mutation, 45% had enzyme elevations compared to only 20% in 25 pancreatic sufficient patients with class IV or V mutations. The prevalence rates for other genotypes ranged from 34 to 60%. The magnitude of the enzyme elevation ...
The mitochondrial and cytosolic branched-chain aminotransferases (BCAT m and BCAT c) are homodimers in the fold type IV class of pyridoxal 5′-phosphate-co... AJL Cooper,SA Bruschi,M Conway,... - 《Biochemical Pharmacology》 被引量: 62发表: 2003年 Determinants of Substrate Specificity in...
Enzymes encoded by genes ota3, ota8, otae6, otae21, otaf1, otaf8, and otaf26 belong to pyridoxine 5'-phosphate-dependent enzyme class IV. These seven 蠅-aminotransferase genes are highly conserved according to phylogenetic tree and bioinformatics analyses, as are the putative lysine catalytic ...
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A leucine/isoleucine aminotransferase and a valine aminotransferase as terminal enzymes of the branched-chain amino acid synthesis (both enzymes belonging to the EC 2.6.1 class) were isolated from chloroplast stroma and purified about 110-fold. The enzymes differed strongly in their substrate ...
The results of fold-type analysis and the consensus amino acid residues found around the active-site lysine residue identified in the present study showed that the enzyme could be classified into class V aminotransferases of fold type I or the AT IV subfamily of the alpha family of the PLP-...
fromsheepbrain.ThesheepBCATccDNA(3kb)encodesamaturepolypeptideof385aminoacidswithacalculatedmolecularmassof43072.93Da.ThesequenceofthesheepBCATccDNAismoresimilartoothermammalianBCATccDNAs(53^87%identical)thantothesheepmitochondrialbranched-chainaminoacidaminotransferase(52%).SheepBCATcbelongstotheIVFoldingclassof...
Aminotransferases play a pivotal role as a crucial category of enzymes that is primarily responsible for the metabolism and transfer of amino acids. Aminotransferases are classified into five classes, including aminotransferase class I and II, aminotransferase class III, aminotransferase class IV, and ...
Non-ATs, cysteine desulfurases, and molybdenum cofactor sulfurase are also found in class IV clade. Class III has d-amino acid and BCATs and is the most structurally distinct AT class that belongs to the independently evolved fold type IV PLP-dependent enzymes (Box 1). This class also ...