we identified an aminopeptidase N-like protein(BtAPN)in B.tabaci Asia II 1,an efficient vector of SLCMV,which is involved in the SLCMV transmission process.Through the use of glutathione S-transferase pull-down assay and LC-MS/MS analysis,we demonstrated the interaction between BtAPN and the...
The human aminopeptidase N (APN) is a ubiquitous transmembrane glycoprotein, with a large extracellular region and a small intracellular NH2-terminal membrane anchor that may lead to an arch-like arrangement on the cell surface, forming and open or a closed conformation [24]. It is a member ...
KBE009: An antimalarial bestatin-like inhibitor of the Plasmodium falciparum M1 aminopeptidase discovered in an Ugi multicomponent reaction-derived peptido... Malaria is a global human parasitic disease mainly caused by the protozoon Plasmodium falciparum. Increased parasite resistance to current drugs ...
like GGT, is synthesized with an uncleaved signal sequence at its N-terminus, which serves as a membrane anchor (Tate 1989). The human enzyme has been shown to possess an additional sorting signal that allows the enzyme to be segregated in thetrans-Golgi network and then to the apical membr...
KBE009: An antimalarial bestatin-like inhibitor of the Plasmodium falciparum M1 aminopeptidase discovered in an Ugi multicomponent reaction-derived peptido... KBE009: An antimalarial bestatin-like inhibitor of the Plasmodium falciparum M1 aminopeptidase discovered in an Ugi multicomponent reaction-derived pep...
The other spots contained proteins that could be excluded as F4acR, like ubiquinol cytochrome C reductase (spots 1 and 2), an enzyme of the mitochondrial respiratory chain, and hemo- globin (spot 3) of red blood cells. Based on these data, porcine aminopeptidase N (pAPN) was further ...
The oxytocinase subfamily of M1 aminopeptidases The placental leucine aminopeptidase (P-LAP), adipocyte-derived leucine aminopeptidase (A-LAP) and leukocyte-derived aminopeptidase (L-RAP) belong to one d... M Tsujimoto,A Hattori - BBA - Proteins and Proteomics 被引量: 232发表: 2005年 Role of...
Mai KT, Bokhary R, Yazdi HM, Thomas J, Commons AS (2002) Reduced HBME-1 immunoreactivity of papillary thyroid carcinoma and papillary thyroid carcinoma-related neoplastic lesions with Hürthle cell and/or apocrine-like changes. Histopathology 40: 133–142 Article CAS Google Scholar Miettinen M,...
APN is anchored to the apical membranes of the kidney proximal tubules by a hydrophobic stretch of amino acids at the N-terminus. The enzyme, as is the case with GGT, can be readily released from membranes by treatment withpapain. The amino acid sequence indicates that this enzyme, like ...
Insulin-regulated aminopeptidase (IRAP, also known as placental leucine aminopeptidase, PLAP) is the third member of the oxytocinase subfamily of M1 aminopeptidases (Tsujimoto and Hattori, 2005). Unlike ERAP1 and ERAP2, which are soluble proteins, IRAP is a type II membrane protein, with ~100...