X-ray crystal structure analysis suggests that targeting the Pf A-M1 active site could be useful for treating malaria.Science-Business eXchangedoi:10.1038/scibx.2009.231NoneSkinner-Adams TS, Stack CM, Trenholme KR, Brown CL, Grembecka J, Lowther J, et al. Plasmodium falciparum neutral ...
A first-in-man phase i and pharmacokinetic study on CHR-2797 (Tosedostat), an inhibitor of M1 aminopeptidases, in patients with advanced solid tumors... AHM Reid,A Protheroe,G Attard,... - 《Clinical Cancer Research》 被引量: 34发表: 2009年 A Comparative Study: Aminopeptidase Activities...
The oxytocinase subfamily of M1 aminopeptidases The placental leucine aminopeptidase (P-LAP), adipocyte-derived leucine aminopeptidase (A-LAP) and leukocyte-derived aminopeptidase (L-RAP) belong to one d... M Tsujimoto,A Hattori - BBA - Proteins and Proteomics 被引量: 232发表: 2005年 Role of...
In contrast to the case with other M1 aminopeptidases, bestatin inhibited the aminopeptidase activity of Laeverin/APQ much more effectively than other known aminopeptidase inhibitors. These results indicate that Laeverin/APQ is a novel bestatin-sensitive leucine aminopeptidase and suggest that the ...
(2017). Generation of AMBER force field parameters for zinc centres of M1 and M17 family aminopeptidases. Journal of Biomolecular Structure and Dynamics. Ahead of Print.doi:10.1080/07391102.2017.1364669Yang, WeiRiley, Blake TLei, Xiangyun
APN is the most extensively studied member of the large M1 family of zinc-dependent aminopeptidases (2). APN is a cell surface-anchored ectoenzyme, with a small N-terminal intracellular domain, a single-pass transmembrane anchor, a small extracellular stalk, and a large C-terminal ectodomain ...
Human aminopeptidase N (hAPN/hCD13) is a dimeric membrane protein and a member of the M1 family of zinc metallopeptidases. Within the rennin-angiotensin system, its enzymatic activity is responsible for processing peptide hormones angiotensin III and IV. In addition, hAPN is also involved in ...
Identification and characterization of CaApe2 – a neutral arginine/alanine/leucine-specific metallo-aminopeptidase from Candida albicans Thomas Klinke1, Andreas Rump2, Roman Pönisch1, Wolfgang Schellenberger3, Eva-Christina Müller4, Albrecht Otto4, Wolfgang Klimm1, Thomas M. Kriegel5 ...
These results suggest that F4ac is a sialic acid-binding lectin and MucosalImmunology | VOLUME 5 NUMBER 6 | NOVEMBER 2012 639 ARTICLES F4R– F4R+ 1 2 34 M 200 150 100 75 50 37 F4R+ F4R– M 12 34 25 20 – + –+ Neuraminidase M1 2 –+ – PNGaseF + M1 2 F4R+ M1 2 –...
Plasmodium falciparum M1-aminopeptidase: a promising target for the development of antimalarials. Curr Drug Targets. 2014;15:1144-65.Gonzalez-Bacerio J, Fando R, del Monte-Martinez A, Charli JL, Chavez Mde L. Plasmodium falciparum M1-aminopeptidase: a promising target for the development of ...