Figure 2.Chemical structure of the bisubstrate analog inhibitor of gentamycin acetyltransferase. More recently, the Auclair group has reported a more extensive investigation of bisubstrate analog inhibitors toward aminoglycoside 6′-N-acetyltransferase (AAC(6′)-Ii) fromEnterococcus faecium. AAC(6′)-Ii...
maltophilia strains in Nepal harbored novel genes encoding a class A β-lactamase, KBL-1, or a 6′-N-aminoglycoside acetyltransferase, AAC(6′)-Iap. ABSTRACT Seven drug-resistant strains of Stenotrophomonas maltophilia were isolated from patients at two university hospitals in Nepal. S. ...
Aminoglycoside phosphotransferase of the bifunctional aminoglycoside acetyltransferase(6′)-Ie-APH(2″)-Ia enzyme from S. aureus was the first characterized enzyme of the APH(2″) class. Regiospecificity of phosphate transfer to 4,6-disubstituted aminoglycosides by this enzyme was experimentally ...
APH(9)-Ia exhibits a similar folding to that of the APH(3 ) and APH(2 ) enzymes, but it differs significantly in its substrate binding area and in the fact that it undergoes a conformational change upon ligand binding. Table 1. N-acetyltransferase (AAC)-modifying enzymes. Enzyme ...