Amino-acids and peptides. Part 46. Synthesis of bradykinin analogues modified in the vicinity of the carboxy-groupIn order to investigate further the effect on biological activity of structural changes in the vicinity of the terminal carboxy-group, the following analogues of bradykinin have been ...
ChemInform Abstract: AMINO ACIDS AND PEPTIDES PART 129, SYNTHESIS AND INHIBITORY PROPERTIES OF OXYTOCIN ANALOGUES MODIFIED IN THE AMINO-TERMINAL REGION OF THE MOLECULEhormonesThe memory-modulating effects of subcutaneously administered oxytocin and related peptides were investigated in the social recognition...
Davis, Franklin A. Temple University, Philadelphia, PA, United States Abstract Alpha-amino acids are the basic building blocks of peptides and proteins, which are responsible for the structure and function of most living things. They are extensively employed as chiral templates and subunits in the...
This invention is related to anti-microbial peptides having the same amino acid sequence and at least the same anti-microbial activity as those of Phylloseptins which are isolated from the skin of Phyllomedusa hypochondrialis. The peptides did not have a
Polytheonamides (A and B)5are cytotoxic linear peptides, isolated from the marine spongeTheonella swinhoei, and are believed to be produced by symbiotic microorganisms. Among the 48 amino acids sequence 13 of them are nonproteinogenic amino acid residues (Fig. 2.9). ...
aminophosphinesalcoholysisacid catalysisWe recently reported the pyrolysis of stabilised ylides as a method for overall conversion of carboxylic acids to homologous acetylenic esters and terminal alkynes.1,2 This has now been applied successfully to amino acids. A wide range of alkoxycarbonyl protected ...
Optimized geometries of the lowest energy conformers of the suggested drugs based on carbohydrate and amino acids at B3LYP/6‐311++G (d, p) level (see Table1for nomenclatures and codes of molecules). Full size image Table 1 The structural information for cytarabine-5′-triphosphate and our ...
new roles for amino acids in physiology and pathophysiology, biology, amino acid analogues and derivatives, polyamines, radiated amino acids, peptides, stable isotopes and isotopes of amino acids. Applications in medicine, food chemistry, nutrition, gastroenterology, nephrology, neurochemistry, pharmacology...
The reaction is tolerant to a wide range of polar functionalities and is suitable for array formats. Ten oxetane analogues of bioactive benzamides and marketed drugs are prepared. Kinetic and computational studies support the formation of an oxetane carbocation as the rate-determining step, followed ...
Domestic cats and dogs are carnivores that have evolved differentially in the nutrition and metabolism of amino acids. This article highlights both proteinogenic and nonproteinogenic amino acids. Dogs inadequately synthesize citrulline (the precursor of&