1c). Sites of cross-linking at the protein were centered at two phenylalanines (F126 and F160), with a distribution of 1-3 amino acids flanking these positions37. This was confirmed from analysis of the MS/MS spectra in which fragment ions localize the RNA adducts unambiguously on the ...
Schuster, W, Brennicke, A (1991) RNA editing in ATPase subunit 6 mRNAs in Oenothera mitochondria, a new termination codon shortens the reading frame by 35 amino acids. FEBS Lett 295: pp. 97-101Stadler PF, Happel R (1992) Correlation structure of the landscape of the graph-bipartitioning-...
2 Transfer RNA recognition During the protein translation process, the polymerization reaction of α-amino acids monomers takes place at the ribosome. Beforehand, a specific selection of the amino acid side chains is carried out in a two-step reaction by a class of enzymes known ...
Transfer RNA Covalently Binds Amino Acids and Recognizes Specific Regions of mRNA How does mRNA specify the sequence of amino acids in a protein? Which amino acid is to be incorporated into the protein is specified by a sequence of three nucleotides called a codon. The mRNA triplets do not di...
The absence of orthogonal aminoacyl-transfer RNA (tRNA) synthetases that accept non-l-α-amino acids is a primary bottleneck hindering the in vivo translation of sequence-defined hetero-oligomers and biomaterials. Here we report that pyrrolysyl-tRNA synthetase (PylRS) and certain PylRS variants ac...
Amino acids are a crucial, yet basic unit of protein, and they contain an amino group and a carboxylic group. They play an extensive role in gene expression process, which includes an adjustment of protein functions that facilitate messenger RNA (mRNA) translation. ...
13. How are most proteases involved in protein digestion initially synthesized? A. As active enzymes B. As inactive zymogens C. As amino acids D. In the form of RNA E. Directly from dietary proteins Answer: B 14. In amino acid catabolism, what is the fate of the amino group in most...
Recent years have witnessed the discovery that amino acids (AA) are not only cell signaling molecules but are also regulators of gene expression and the pr
In biological systems, these amino acids are the building blocks of proteins. Under the direction of messenger RNA during protein synthesis, the amino and carboxyl side chains of two amino acids are condensed chemically on the ribosome, which acts as an amino acid polymerase. This reaction ...
Mechanistically, Rab1A mediates AA-mTORC1 signaling, particularly branched chain amino acids (BCAA), to regulate the stability and localization of the insulin transcription factor Pdx1. Collectively, these results reveal a physiological role of aa-Rab1A-mTORC1 signaling in the control of whole-body...