Kim, J. and Guan, K.L. (2011) Amino Acid Signaling in TOR Activation. Annual Review of Biochemistry, 80, 1001- 1032. http://dx.doi.org/10.1146/annurev-biochem-062209-094414Kim J, Guan KL. Amino acid signaling in TOR activation. Annu Rev Biochem 2011; 80:1001-1032....
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Amino acid signaling in TOR activation. Annu Rev Biochem. 2011;80:1001-1032; doi:10.1146/annurev-biochem-062209-094414.. Google Scholar [85] Kim SG, Buel GR, Blenis J. Nutrient regulation of the mTOR complex 1 signaling pathway. Mol Cells. 2013;35(6):463-473; doi:10.1007/s10059-...
because these receptors are distantly related to ionotropic glutamate receptors (iGluRs)27,34,35. iGluRs are best known for their role in mediating synaptic transmission, but homologues in prokaryotes and plants have been suggested to function as more broadly-tuned amino acid sensors36,37. In the...
Guan Amino acid signaling in TOR activation Annu. Rev. Biochem, 80 (2011), pp. 1001-1032 CrossrefView in ScopusGoogle Scholar 5 J.L. Jewell, R.C. Russell, K.L. Guan Amino acid signalling upstream of mTOR Nat. Rev. Mol. Cell Biol, 14 (2013), pp. 133-139 CrossrefView in Scopus...
However, the well-characterized nutrient sensors of mTOR, such as Sestrin for leucine, CASTOR for arginine, and SAMTOR for SAM, are not evolutionarily conserved in unicellular organisms60. Here, we characterized mitoSIR signaling in the budding yeast S. cerevisiae. This SAM-responsive programming ...
Target of Rapamycin (TOR) mediates a signalling pathway that couples amino acid availability to S6 kinase (S6K) activation, translational initiation and cell growth. Here, we show that tuberous sclerosis 1 (Tsc1) and Tsc2, tumour suppressors that are responsible for the tuberous sclerosis syndrome...
Little is known about the role of amino acids in cellular signaling pathways, especially as it pertains to pathways that regulate the rate of aging. However, it has been shown that methionine or tryptophan restriction extends lifespan in higher eukaryote
Amino acid homeostasis is maintained by import, export, oxidation, and synthesis of nonessential amino acids, and by the synthesis and breakdown of protein. These processes work in conjunction with regulatory elements that sense amino acids or their metabolites. During and after nutrient intake, amin...
In this study, we examined the effect of dietary amino acids to modulate food intake in adult fruit flies and sought to identify additional amino acid sensor. We found that dietary amino acids significantly promoted food intake independent of Ir76b signaling as well as flies’ internal nutritional...