Amino acid signaling in TOR activation. Annu Rev Biochem 2011;80:1001-32.KIM J,GUAN K L. Amino acid signaling in TOR ac- tivation[J]. Annual Review of Biochemistry,2011, 80: 1001 - 1032.KIMJ ; GUAN K L.Amino acid signaling in TOR activation.Annual Review of Biochemistry.2011.1001-...
Evidence exists for both an intracellular and/or a membrane bound sensor for amino acid mediated mTOR activation. Research in eukaryotic models, has implicated amino acid transporters as nutrient sensors. This review describes recent advances in nutrient signaling that impinge on mTOR and its targets ...
The presence of certain amino acids, such as leucine, permits activation of the master growth regulating kinase TOR (target of rapamycin). These two signal transduction pathways react to amino acid deprivation by inhibiting general protein translation while at the same time increasing translation of ...
In this report, we present an amino acid (aa) sequence alignment of TORI (DRR1) and TOR2 (DRR2) and identify conserved and nonconserved motifs within the N-terminal domain that are indicative of possible nuclear localization. We also show that the mutations responsible for Rm resistance in ...
(B) Amino acid starvation inhibits insulin mRNA expression. MIN6 cells were cultured in normal or aa starvation medium for 2 h. Ins1 and Ins2 mRNA expression was determined by qRT-PCR. Triplicates were used (n = 3). (C) Amino acid is required for glucose to stimulate insulin mRNA expre...
www.nature.com/scientificreports OPEN A molecular and neuronal basis for amino acid sensing in the Drosophila larva received: 18 July 2016 accepted: 20 September 2016 Published: 16 December 2016 Vincent Croset1,†, Michael Schleyer2, J. Roman Arguello1, Bertram Gerber2,3,4 & ...
nature.com/cdd The TORC1 inhibitors Nprl2 and Nprl3 mediate an adaptive response to amino-acid starvation in Drosophila Y Wei1 and MA Lilly*,1 Target of rapamycin complex 1 (TORC1) is a master regulator of metabolism in eukaryotes that integrates information from multiple upstream signaling ...
Amino acid metabolism plays important roles in tumor biology and tumor therapy. Accumulating evidence has shown that amino acids contribute to tumorigenesis and tumor immunity by acting as nutrients, signaling molecules, and could also regulate gene tran
The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1.Science. 2008; 320: 1496-1501Crossref PubMed Scopus (1732) Google Scholar). How amino acids enter the cell to regulate mTORC1 activation is currently unknown. In the present study we identify the mechanism by which L-...
The differential metabolites between the DR and control groups were mainly organic acids (including amino acid), and amines. These metabolites are involved in metabolic pathways such as amino acid metabolism. Further analysis showed that, the levels of 17 amino acids were significantly changed in ...