Fumarola C, La Monica S, Guidotti GG (2005) Amino acid signaling through the mammalian target of rapamycin (mTOR) pathway: role of glutamine and of cell shrinkage. J Cell Physiol 204(1):155–165. : 10.1002/jcp.20272Fumarola, C, Monica, S, Guidotti, GG (2005) Amino acid ...
Amino acid signalling upstream of mTOR Nat. Rev. Mol. Cell Biol., 14 (2013), pp. 133-139 CrossrefView in ScopusGoogle Scholar Jewell et al., 2015 J.L. Jewell, Y.C. Kim, R.C. Russell, F.-X. Yu, H.W. Park, S.W. Plouffe, V.S. Tagliabracci, K.-L. Guan Metabolism. Diff...
Amino acid signalling up- stream of mTOR. Nat Rev Mol Cell Biol 2013; 14:133-139. 22 Sancak Y, Peterson TR, Shaul YD, et al. The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1. Science 2008; 320:1496-1501. 23 Hara K, Yonezawa K, Weng QP, Kozlowski MT, ...
Glutamine (Gln) is a conditional EAA, which is not essential for normal cells but becomes crucial for tumor cells due to their heightened demand. It is the most abundant amino acid found in plasma, and the most rapidly consumed amino acid in tumor cells [11]. As an EAA in tumors, gluta...
Activation of autophagy and elevation of glutamine synthesis represent key adaptations to maintain amino acid balance during starvation. In this study, we investigate the role of autophagy and glutamine on the regulation of mTORC1, a critical kinase that regulates cell growth and proliferation. We rep...
Figure 1. The Amino Acid Sensing Pathway Upstream of mTORC1 Schematic detailing the key molecular players in the nutrient sensing branch upstream of mTORC1. SLC38A9 The fact that this important growth regulatory pathway centers on the surface of the lysosome led to the prediction that nutrients,...
transmit specific amino acid signals to the mTORC1 pathway. 概要 哺乳动物雷帕霉素靶蛋白复合物 1 (mTORC1) 能够感受一系列细胞内外的环境因素 (如氨基酸), 从而控制细胞生长和代谢。在过去的几十年里, 众多蛋白被发现能够参与受氨基酸调控的 mTORC1 信号通路中。Rag GTPases 能够将氨基酸的信号传递给 mTORC1...
recent work has revealed that PR61, a B56 family regulatory subunit of PP2A (protein phosphatase 2A), associates with and regulates the activity of MAP4K3 (mitogen-activated protein kinase kinase kinase kinase 3), a protein kinase regulated by amino acid sufficiency that acts upstream of mTORC1...
Amino-acids stimulate the mammalian target of rapamycin complex(mTORC)1; mTORC1 integrates amino-acid and energy-sensing pathways in beta-cells. Rapamycin ... N Tatevian,S Alexandrescu,M Covinsky,... - 《Annals of Clinical & Laboratory Science》 被引量: 49发表: 2010年 Protein-leucine fed ...
16 $ 32.00 www.nature.com/cr npg Multiple amino acid sensing inputs to mTORC1 Mitsugu Shimobayashi1, Michael N Hall1 1Biozentrum, University of Basel, Basel, Switzerland The evolutionarily conserved target of rapamycin complex 1 (TORC1) is a master regulator of cell growth and me- tabolism...