Amino acid metabolism plays important roles in tumor biology and tumor therapy. Accumulating evidence has shown that amino acids contribute to tumorigenesis and tumor immunity by acting as nutrients, signaling molecules, and could also regulate gene transcription and epigenetic modification. Therefore, targ...
In mammals, amino acid metabolism has evolved to control immune responses. Autoimmune diseases are heterogeneous conditions that involve the breakdown of tolerogenic circuitries and consequent activation of autoreactive immune cells. Therefore, critical enzymes along amino acid degradative pathways may be ...
Amino acids play a key role in the proliferation, development, and immune response of immune cells. This review summarizes the effects of amino acids on intestinal immune function of piglets, and the mechanism of glutamine, γ-aminobutyric acid, arginine and tryptophan in regulating immune cell fat...
in the tricarboxylic acid cycle19,20. Various diseases caused by abnormal amino acid metabolism are known to affect brain function. For example, maple syrup urine disease, which is due to an inborn error in metabolism caused by decreased activity of the branched-chain keto acid dehydrogenase ...
Gene set enrichment analysis (GSEA) identified several significant gene ontology (GO) terms, among others associated with amino acid metabolism and mitochondrial metabolism, in cells exposed to fluid shear stress compared to static control (Fig. 2b and Additional file 1: Table S1). Fig. 2 FSS ...
They are formulated to provide essential nutrients necessary for energy production and immune function.For Weight Loss. Amino acid supplements are increasingly recognized for their potential to aid in weight loss efforts. By supporting metabolism and suppressing appetite, they can assist in achieving and...
Rees WD, Wilson FA, Maloney CA (2006) Sulfur amino acid metabolism in pregnancy: the impact of methionine in the maternal diet. J Nutr 136:1701S–1705S PubMed CAS Google Scholar Rhoads JM, Wu G (2008) Glutamine, arginine, and leucine signaling in the intestine. Amino Acids. doi:10.100...
Fundamentally, there are 6 contributors to amino acid homeostasis in mammalian cells, namely 1) import, 2) export, 3) metabolism, and 4) synthesis of nonessential amino acids, 5) protein synthesis, and 6) protein breakdown (Figure 1). These processes work in conjunction with regulatory element...
Glutamine is an amino acid that serves as a building block for proteins. It is also an important fuel for immune cells that promote optimal immune function. Best Seller Super Carnosine Muscle & exercise support, heart health, antioxidant defense ...
The effect of spinetoram on amino-acid metabolism of fall armyworm, Spodoptera frugiperda (J.E. Smith), was investigated, at the dose of LC10 and LC90, by transcriptome and LC-MS/MS analysis. Using statistics-based analysis of both POS and NEG mode, a total of 715,501 metabolites in ...