cysteine, and tyrosine), and are less sensitive to amino acid imbalances and antagonisms. Throughout adulthood, cats and dogs may lose 34% and 21% of their lean body mass, respectively. Adequate intakes of high-quality protein (i.e., 32% and 40% animal protein in diets of aging dogs a...
Sulfur-containing compounds include sulfur-containing amino acids and their metabolites (methionine, cystine, cysteine, homocysteine, taurine, cysteic acid, and cystathionine), thiamine, biotin, lipoic acid, coenzyme A, glutathione, chondroitin sulfate, cartilage mucopolysaccharides, and fibrinogen. Most of...
Editor of this volume is an internationally recognized expert in the biochemistry, nutrition and physiology of amino acids. He has over 38 years of experience with research and teaching at world-class universities in the area of amino acid biochemistry, nutrition, and physiology. He has published ...
Providing many other cellular metabolites to C. elegans also increased longevity suggesting that anaplerosis of tricarboxylic acid (TCA) cycle substrates likely plays a role in lifespan extension. Conclusions Supplementation of C. elegans with 18 of the 20 individual amino acids extended lifespan, but...
Studies at the molecular level demonstrate that dietary amino acid intake produces substantial effects on health and disease by modulating metabolism. However, how these effects may manifest in human food consumption and dietary patterns is unknown. Here
The unique structure of praline (and its hydoxylated derivative, hydroxyproline) causes this amino acid to play a unique role in protein structure. The amino acids with positively charged (basic) r groups at ph 6-7 are lysine; argiine has a positively charged quanidino group. At ph 7.0...
A BCAA dysmetabolism model proposes that the accumulation of mitotoxic metabolites (and not BCAAs per se) promotes β-cell mitochondrial dysfunction, stress signalling and apoptosis associated with T2DM. Alternatively, insulin resistance might promote aminoacidaemia by increasing the protein degradation ...
The intensities of metabolites related to amino acid metabolism (A) and fatty acid metabolism (B).Joong, Kyong AhnSooah, KimJiwon, HwangJungyeon, KimYou, Sun LeeEunMi, KohKyoung Heon, KimHoonSuk, Cha
were observed in persistent AF patients. The feature AAs identified by machine learning algorithms were glutamic acid and methionine. The association between AAs and age differs between AF and control subjects. Distinct patterns of AA metabolic profiles were observed in the myocardial metabolites of age...
The predictive accuracy has been improved by component coefficient method (Zhang and Chou, 1992), expressing the protein as a vector of 20 dimensional space, in which its 20 components are defined by the composition of 20 amino acid residues. Similar approach on the weighting to the 20 constitu...