Bacterial D-amino acid transaminase catalyzes the synthesis of D-glutamate and D-alanine for the bacterial cell wall peptidoglycan. The enzyme is likely present in all bacteria but is absent in mammalian cells. The mechanism of action of several enzyme-activated inhibitors (suicide substrates) of ...
ACTIVITY : Antiviral; antibacterial; cytostatic; anti-apoptotic; vasotropic; hemostatic. No supporting data given. MECHANISM OF ACTION : Gene or protein replacement; gene therapy. No supporting data given. 展开 收藏 引用 批量引用 报错 分享
elegans as knockdown of an enzyme that catabolizes tryptophan increased lifespan [27]. Unexpectedly, knockdown of an aromatic amino acid transporter also extended lifespan [28], suggesting that decreased tryptophan or other aromatic amino acid levels may also boost longevity. Others found that ...
To determine if the mechanism of amino acid loading in improving postischemic function was enhancement of high-energy phosphate resynthesis, nucleotides and nucleosides were measured. While all preischemic values were equivalent, amino-acid-loaded hearts had significantly greater high energy nucleotides at...
requires cellulose to proliferate in the intestinal tract, might be associated with the mechanism of action by which BCAAs alleviate fat accumulation in the liver. The acetic acid transported to the liver is activated to acetyl-CoA with the concomitant formation of AMP. The increase in AMP ...
The effect of various amino acids on production of γ-PGA by Bacillus subtilis Z15 was investigated. The γ-PGA yield was increased 23.18%, 12.15% and 31.46%, respectively, with 3 g/L aspartic acid (0 h), 1.5 g/L phenylalanine (0 h) and 7 g/L glutamic acid (24 h)...
aged AF mice. Aged AF mice had lower levels of Betaine, L-histidine, L-alanine, L-arginine, L-Pyroglutamic acid, and L-Citrulline compared with adult AF mice. Aged AF mice also presented a different gut microbiota pattern, and its functional prediction analysis showed AA metabolism alteration...
(human chorionic gonadotropin), and TSH. Chains are noncovalently linked and are glycosylated, particularly with sialic acid. The two forms of rhFSH, follitropin alpha and follitropin beta have the same amino acid sequence and are pharmacologically equivalent, but they differ slightly in ...
The differential metabolites between the DR and control groups were mainly organic acids (including amino acid), and amines. These metabolites are involved in metabolic pathways such as amino acid metabolism. Further analysis showed that, the levels of 17 amino acids were significantly changed in ...
Depriving cells of a single essential amino acid decreased PRPP synthetase activity with a half-life of ~ 8 h, and combining cisplatin and amino acid deprivation synergistically reduced intracellular PRPP. PRPP is a rate-limiting substrate for purine nucleotide synthesis, and cisplatin inhibited ...