(2016). Presymptomatic alterations in amino acid metabolism and DNA methylation in the cerebellum of a murine model of niemann-pick type c disease. Am. J. Pathol. 186, 1582-1597. doi: 10.1016/j.ajpath.2016.02.012Kennedy, B. E., Hundert, A. S., Goguen, D., Weaver, I. C., and ...
degradation, filtration, reabsorption and excretion of amino acids, acting to retain useful metabolites while excreting potentially harmful and waste products from amino acid metabolism. A complex network of kidney
Cells were cultured in RPMI 1640 medium containing 10% fetal bovine serum (Gibco), 4 mM Gln, 100 U/mL penicillin, and 100 μ;g/mL streptomycin (Gibco). For experiments conducted under amino acid–deprived conditions, MM cells were grown in amino acid–free medium (Minimal Essential Medium,...
Methionine is an essential amino acid associated with proper methylation supportive of the liver, brain, and DNA. It is one of only two sulfur-containing amino acids common among dietary proteins and essential to sulfur-dependent processes.
Amino acid metabolism (AAM) reprogramming plays a crucial role in hepatocellular carcinoma (HCC), but its genetic pathophysiology was not fully elucidated. Therefore, we employed a summary data-based Mendelian randomization (SMR) approach to identify putative causal effects of the AAM-related genes on...
representing in the lower-left panel. The upper-left box represents the metabolism of tryptophane and phenylalanine. AAAD indicates aromatic L-amino acid decarboxylase; Ala, alanine; AO, aldehyde oxidase; Arg, arginine; Asn, asparagine; Cys, cysteine; DBH, dopamine β-hydroxylase; GBM, glioblastom...
Metabolic reprogramming of amino acids has been increasingly recognized to initiate and fuel tumorigenesis and survival. Therefore, there is emerging interest in the application of amino acid metabolic strategies in antitumor therapy. Tremendous efforts
Cellular amino acid uptake is critical for mTOR complex 1 (mTORC1) activation and cell proliferation. However, the regulation of amino acid uptake is not well-understood. Here we describe a role for asparagine as an amino acid exchange factor: intracellu
Biosynthetic pathways, like bioenergetic pathways, also rely on various amino acid contributors. Through acetyl-CoA synthesis, lipogenesis can be mediated by catabolism of BCAAs3. Nucleotide synthesis, which can be delineated into purine and pyrimidine biosynthesis, is another amino acid-dependent process...
into BCKAs that were incorporated into tissue protein,nonessential amino acidand nucleotides as nitrogen donors, whereas PDAC tumors have decreased BCAA metabolism due to suppressed expression of BCAT2 [111]. These two studies indicate that cancer tissue of origin rather than oncogenic mutation ...