Silencing of DcROS1 accelerated while overexpression of DcROS1 delayed carnation flower senescence.Moreover, among the hypermethylated differentially expressed genes during flower senescence, we identified two amino acid biosynthesis genes, DcCARA and DcDHAD, with increased DNA methylation and red...
degradation, filtration, reabsorption and excretion of amino acids, acting to retain useful metabolites while excreting potentially harmful and waste products from amino acid metabolism. A complex network of kidney
These data suggest that primary changes in amino acid transport and intracellular levels do not occur in acute cardiac hypertrophy and that the hypertrophy process is characterized by a coordinated increase in both muscle mass and amino acid content. 展开 ...
and transport, has provided numerous targets for the development of drugs. Amino acid-degrading enzymes such as arginase and asparaginase have been shown to exert antitumor effects in preclinical and clinical settings;30,31,32,33,34however, additional pathways involving amino acid transport and synthes...
We have previously reported a significant alteration of AAs and their derivative BAs in serum samples of FEP patients11. According to the study, AP-naïve FEP patients had significantly higher levels of taurine and spermine, whereas the values of Pro, and alpha-aminoadipic acid (alpha-AAA) ...
DNA is specific in coding a particular sequence of amino acids. Each protein consists of one or more polypeptide chains. Proteins are polymers of 50 or more amino acids, while peptides are shorter amino acid polymers. A protease, which is also known as peptidase or proteinase, is an enzyme...
it always functions as the rate-limiting molecule of the cell reproductive cycle. Once deprived of glutamine, cancer cells usually arrest in S-phase [13]. Additionally, glutamine also plays a crucial role in maintaining redox homeostasis, replenishing the tricarboxylic acid (TCA) cycle, and partici...
Mechanism of inhibition of enzymic deoxyribonucleic acid methylation by 2-(acetylamino)fluorene bound to deoxyribonucleic acid Binding of 2-(acetylamino)fluorene (AAF) to C-8 of guanine induces a local destabilization of the DNA helix. A relationship was observed where the degree o... A Pfohl-...
Amino acids are the building blocks of protein synthesis. They are structural elements and energy sources of cells necessary for normal cell growth, differentiation and function. Amino acid metabolism disorders have been linked with a number of pathologi
Amino acid abnormalities are observed in a broad spectrum of inherited metabolic diseases, such as disorders of amino acid metabolism and transport, organic acidemias, and ureagenesis defects. Comprehensive analysis of physiologic amino acids in blood, u