This is why only 10 years have passed since the first KA reaction was reported (i.e. the one-pot coupling of a ketone with an amine and an alkyne towards quaternary propargylamines). The present review article provides a brief introduction to multicomponent reactions, the existing conventional ...
Ketone–Amine–AlkyneNon-conventional approachThe KA2coupling reaction is a well-explored and versatile method for forming C–C bonds in synthetic chemistry. It is composed of ketone, amine, and alkyne, which play a major role in the synthesis of propargylamines, known for their diverse ...
A ketone’s reaction with ammonia, followed by sodium cyanoborohydride’s catalytic reduction or degradation, produces a 1 ° amine. N-replaced amines are generated by ketone reaction with primary amines, followed by reduction. N, N-replaced amines can be produced by 2° amine reaction with ...
However, when the ketone or aldehyde reagents contain a keto or alkyl halide functional group, the amination is unsuccessful (Fig. 6e,f). On the contrary, the reductive coupling gave the desired amines in synthetically useful yields (Fig. 6e,f). Mechanistic investigation. A number of ...
Amine synthesis by reductive amination (reductive alkylation)
Topic: Amine and Heterocyclic reaction (Read 12437 times) CH3CH2NH2 + CH3CO-O-COCH3 --> CH3CH2-NH-COCH3 + CH3COOH Question: explain why only one amine hydrogen which is get substituted by acetyl group eventhough acetate anhydride is used excessively in the reaction??
The enantioselective Michael reaction of ketone lithium enolates using a chiral amine ligand ( 1 ) was studied. Michael adducts ( 4 ) of up to 94% ee were obtained by the reaction between methyl ketones ( 2 ) and Michael acceptors ( 3 ) having a benzylidene group.doi:10.1002/chin....
Ketone–Amine CopolymerCT-InteractionPhosphorescenceLaser PhotolysisKetyl RadicalPoly(4-vinylbenzophenonePoly[4-(2-naphthoyl)styrenePolymer Journal, official journal of the Society of Polymer Science, Japan publishes high quality papers in all areas of polymer and macromolecular research....
Direct catalytic three component Mannich reaction of aliphatic ketone, aldehyde and amine was described in the presence of a catalytic amount of nano-Mn(HS... M Hojjati-Rad,H Eshghi,SM Seyyedi,... - 《Journal of the Iranian Chemical Society》 被引量: 0发表: 2016年 Highly Enantioselective...
摘要: The asymmetric synthesis of the 2,3,6-trisubstituted piperidine core of the antitumor Nuphar alkaloids was readily achieved by using the intramolecular Mannich reaction and a sulfinimine-derived β-amino ketone.被引量: 16 年份: 2006 ...