The carbonyl group at the 2-position in (236) can be aminated directly using methylamine but the reactivity at this position can be easily enhanced by thiation (p. 617), phosphorylation (p. 618) or conversion to the imidoyl chloride. Similar activation of a 5-oxo group by thiation has...
Facile conversion of nitrile to amide on polymers of intrinsic microporosity (PIM-1). Polymer 2016, 98, 244-251.Yanaranop, P.; Santoso, B.; Etzion, R.; Jin, J. Facile conversion of nitrile to amide on polymers of intrinsic microporosity (PIM-1). Polymer 2016, 98, 244-251. [Cross...
Nitriles can be hydrolyzed to primary amides. Since primary amides can further hydrolyze to carboxylic acids, the hydrolysis conditions need to be controlled. Currently, there are many reported methods, sometimes requiring the selection of acidic, basic, or neutral hydrolysis conditions based on...
Fatty amines are commonly prepared through the nitrile process: the fatty acid is reacted with ammonia under metal oxide catalyst to form a fatty nitrile and subsequently hydrogenated with Rainey-Nickel catalyst to produce the fatty amine [42]. Fatty amides are synthesized from fatty acid and ...
Hexanoamide is the most rapidly hydrolysed substrate for amidase from Aspergillus nidulans. Zirconium mediated conversion of hexanoamide to hexanenitrile has been reported 关联靶点(人) 关联靶点(其它物种) 名称和识别符 数据库链接 化学和物理性质 ...
Powner and co-workers have shown that α-aminonitriles, such as Gly-CN, react more readily as nucleophiles with α-amidothioacids than amino acids, owing to their substantially lower pKacompared to amino acids7. Gly-CN could be ligated to Ac-Gly-SH over a broad pH range (pH 5–9), ...
c OH R1 O d R1 e R1 + N R2' Δ Ru-cat. H2O2 Mn-cat. R1' Figure 1 | Atom-efficient approaches to amide bond formation. (a) Thermal or Lewis acid-mediated dehydration of ammonium carboxylates. (b) Catalytic addition of alcohols to nitriles. (c) Dehydrogenative coupling of alcohols ...
Improved thermoplastic elastomeric compositions adopted for easy conversion, e.g., by injection molding or extrusion techniques, into useful shaped articles having good abrasion and tear resistance, a
The present invention relates to a method of producing an amide which comprises subjecting a nitrile to the action of a microorganism belonging to the genus Rhodococcus and having the ability to hydra
Special emphasis is placed upon the range of functional groups that are acceptable by enzymes and/or survive under the transformation, as well as the advantages as a synthetic tool for conversion under mild conditions. 关键词: nitrile amide hydrolysis microorganisms organic synthesis DOI: 10.1271/...