amideAliphatic and aromatic nitriles are converted to corresponding amides in a single step via hydrolysis with basic H2O2 in aqueous solution of the surfactant Cetyltrimethylammonium methanesulfonate (CTAOMs). The method has several advantages: use and recycle of water as reaction medium, use of ...
2,2,6,6-Tetramethylpiperidin-l-ol and its derivatives generated from the corresponding nitroxide free radicals and L-ascorbic acid in water were used for hydration reaction without separation leading to a simplification in the experiment. 展开 ...
], which showed that the absolute α-carbon configuration in the substrate had a great effect on the acid/amide ratio. Furthermore, a low temperature and increased pH prompted the reaction towards amide. Meanwhile, the electron-withdrawing substituents at the α-position tended towards amide ...
acetamide was noticed in the reaction involving enzymatic hydrolysis of acetonitrile with whole cells of Corynebacterium (Fukuda et al., 1971) and Nocardia rhodochrous LL100-211 (Digeronimo and Antoine, 1976), however, the enzyme system responsible for this conversion of nitrile to amide was not ...
ChemInform Abstract: NITRILE‐FORMAMIDE ADDUCTS. 4. REACTION OF NITRILE‐FORMAMIDE ADDUCTS. SYNTHESIS OF N‐THIOACYLAMIDE DERIVATIVES AND AZA ANALOGS OF THIOPYRYLIUM SALTSthiazine derivativesBei Einwirkung von Na-thiosulfat auf die Immoniumsalze (I) entstehen die Thioacylformamidine (II).doi:10.1002...
A method for the selective hydration of nitrile to amide by employing commercially available acetaldoxime and inexpensive oxometallate such as molybdate, vanadate, and tungstate in environmentally friendly water is described. Under this protocol, nitriles including aromatic nitriles, heterocyclic nitriles,...
In the present study, the iron-catalyzed dehydration of a range of amides to the corresponding nitriles by using N-methyl-N-(trimethylsilyl)trifluoroacetamide (MSTFA) as the dehydration reagent has been explored. After investigating different reaction parameters (e.g., iron source, solvent, cataly...
Sign in to download full-size image Scheme 14. Nitrile hydrolysis by whole cells from Rhodococcus sp.110 Table 1. Isolated yields and ee values for nitrile hydrolysis by whole cells from Rhodococcus sp. (after a reaction time of 24 h)110 EntrySubstrateNitrile %Amide %Acid %Microorganism (ee...
Hydrolysis of nitrile functionality has been a crucial synthetic approach to produce important amides and carboxylic acids, since it also allows for carbon chain extensions. Chemically, the hydrolytic reaction proceeds in an aqueous medium to yield carboxylic acid via amide formation; however, the react...
;CONSTITUTION: A carboxylic amide is made to react with phosphorus pentoxide, phosphorus pentachloride, acetic anhydride, chloroformic ester, phosphorus oxychloride or phosgene as a dehydrating agent using 2-methyl-5-ethylpyridine as a solvent at -50°C to 200°C, preferably -20°C ...