74. Peptide (Amide) CouplingRoman Valiulin
Transition dipole coupling (TDC) is often regarded as a principal mechanism for vibrational coupling that is the basis for the conformational sensitivity of amide vibrations in peptides and proteins. We have computationally tested the relative contribution of TDC to coupling of amide I bands in model...
Traditional amide coupling of acids and amines is, however, increasingly unsustainable, requiring stoichiometric amounts of costly and deleterious coupling reagents as well as undesirable organic solvents, all of which create significant problems in purification and waste processing (Fig. 1A)3. Atom ...
Application of epimerisation-free amide coupling conditions to the synthesis of matrix metalloprotease inhibitor intermediates. Tetrahedron 1998;54:13825-32.Fray, et al, " Application of Epimerisation-Free Amide Coupling Conditions to the Synthesis of Matrix Metalloprotease Inhibitor Intermediates ", ...
Amide bond formation is a fundamentally important reaction in organic synthesis, and is typically mediated by one of a myriad of so-called coupling reagents. This critical review is focussed on the most recently developed coupling reagents with particular attention paid to the pros and cons of the...
Calibration of the angular dependence of the amide proton-C α proton coupling constants, 3 J HN α , in a globular protein ☆ : Us... Three-dimensional porous coordination polymer functionalized with amide groups based on tridentate ligand: selective sorption and ca... ...
Herein, we report a green, expeditious, and practically simple protocol for direct coupling of carboxylate salts and ammonium salts under ACN/H2O conditions at room temperature without the addition of tertiary amine bases. The water-soluble coupling reagent EDC·HCl is a key component in the reacti...
63−and trimethylated poly-L-lysine (pLys(Me)3) at charge stoichiometry. The pLys(Me)3was chosen to avoid the ε-coupling of Lys-NH2, although the pKaof the Lys ε-amino group is significantly higher than any α-amino group. To study the amide bond formation in coacervate droplets,...
The invention relates to compounds of the general formula I <IMAGE> in which A comprises a functional group which is suitable for coupling to compounds which undergo selective accumulation, and R<1>, R<2>, R<3>, R<4> and R<5> may have a variety of meanings. B is a group which is...
In the long history of peptide synthesis, a significant number of active coupling reagents have been abandoned because the highly active electrophilic species generated are usually susceptible to side reactions such as epimerization. The concept presented herein should renew interest in the use of these...