Transition dipole coupling (TDC) is often regarded as a principal mechanism for vibrational coupling that is the basis for the conformational sensitivity of amide vibrations in peptides and proteins. We have computationally tested the relative contribution of TDC to coupling of amide I bands in model...
Counrer[gegen]ion 反荷离子 Coupling reaction 偶联反应 Cram’s rube 克拉姆规则 Cross aldol condensation 交叉羟醛缩合 Cross conjugation 交叉共轭 Cross-coupling reaction 交叉偶联反应 Cyanoethylation 氰乙基化 Cyanomethylation 氰甲基化 Cyclization 环化 Cycloaddition 环加成 Deactivating group 钝化基团 Deamination ...
A competitive coupling of amide anion over menthyl propionate anion with aryl radicalin photo-SRN 1 mechanism was encountered. The rcaction afforded N-aryl propionic amide in excel-lent yield. In contrast, the expected nucleophilic photo-SRN 1 substitution originating from the carb-anion was ...
with a nitrile appended by a short alkyl chain, may be accepted by the NHase. This proved to be the case, using the larger and more valuable nitrile coupling partner as the limiting reagent. Desired conjugates of 4-hydroxy-quinoline (51), 4-methyllumbelliferone (52) and estradiol (53)...
However, a correct application of the ECM necessitates several prerequisites: knowledge of the molecular conformation; knowledge of transition moment direction; and preeminence of the exciton coupling mechanism with respect to other sources of CD signals. In recent years, by using quantum-chemical CD ...
The molecular mechanism of the biological activity was not studied. Show moreView chapterExplore book Reactivity of Six-membered Rings Alan R. Katritzky, ... Viktor V. Zhdankin, in Handbook of Heterocyclic Chemistry (Third Edition), 2010 3.2.3.7.4 Pyridones, pyrones, and azinones: ...
The mechanism of action in organic synthesis is the nucleophilic attack of the amide anion on the acidic hydrogen atom, resulting in the formation of a new bond and the removal of a proton. Desiccant: Lithium amide can also be used as a desiccant, which is a substance that removes ...
Mechanistic experiments were conducted to elucidate the mechanism of these reactions. Firstly, the experiment for differentiating the reactivity of triethylsilane and triethylgermane was performed, interestingly, delivering the sole Ge–H bond insertion product72in an 80% yield with excellent selectivity (...
DFT calculation can also support the reaction mechanism of Se–H insertion and S–H insertion reactions under catalyst-free conditions. The insertion reaction of amide-sulfoxonium ylide 1a with Se–H substrate (i.e. phenylselenol) and S–H substrate (i.e. p-toluenethiol) via the transition ...
cells.jA model of the mechanism by which GA-amide inhibited cell invasion and induced cell apoptosis in glioma. The data are presented as the mean ± SEMs (n = 3). *P < 0.05, **P < 0.01, ***P < 0.001 compared with the control group by 2-tailed Student’st...