[Problems] A compound, which is useful as an active ingredient of a pharmaceutical composition, for example, a pharmaceutical composition for treating chronic renal failure and/or diabetic nephropathy, is provided. [Solving Means] The present inventors have conducted extensive studies on a compound ha...
NOVEL AMIDE STRUCTURE-HAVING PYRIMIDINE COMPOUND AND MEDICINE CONTAINING THE SAMEPROBLEM TO BE SOLVED: To provide a compound that shows strong inhibitory action against cholesterol ester transferring protein (CETP), has good oral absorptivity and gives high concentration in blood.OGIYA TADAAKI...
doi:10.1002/chin.198244006JACOBS, HHARBRECHT, BWILEY‐VCH Verlag GmbHChemischer InformationsdienstTrilithium sodium amide (Li3Na (NH2)4), a compound with a structure related to lithium amide. H. Jacobs,B. J. Harbrecht. Journal of the Less common Metals . 1982...
The compound may contain more than one functional group. Identify and name the functional groups in the following compound. Identify and name the functional groups in the compound below. Identify the functional groups in the following alanine compound. Identify the functional groups in the ...
Amide Structure Let us look at the amide structure. (Image will be Uploaded soon) To remember the amide structure, all you need to remember is that an amide compound must have a nitrogen atom. The carbonyl group is composed of two carbon atoms that are double bonded to an oxygen atom. ...
Compound numberOligomer structuremnOriginaDetectionbRef. (152–156) 1 2–6 D G 81 (157), (158) 2 1, 3 D, S A 77–79 (159) 3 1 D G 77 (160) 4 1 D G 77 (161–166) 5 1–6 D, CD C, G 13, 77 (167) > 6 S G 34, 80 (168–174) — 2, 4–9 D G 81 (...
4b). This compound serves as a possible intermediate for the esterification process. Upon heating compound INT-3z at 100 °C in n-BuOH for several hours, ester 2z was obtained with a high yield of 88% (Fig. 4b). The isolation and conversion of INT-1z and INT-3z demonstrate that ...
(AUC), which equates to a Bru:Bluof 0.32, assuming brain tissue and ppb are equal. In the dog, the compound also penetrated the CNS, CSF:Pl 0.023, which when corrected for free plasma concentrations equates to CSF:Pluof ≥2.3, although this value could be significantly overestimated due...
A process for obtaining an amide of the general formula R-(CO)-NH-CH2-X involves contacting a nitrile of the general formula R-CN with: a) an acid; and c) an alkoxy-containing compound comprising at least one alkoxy functionality of the general formula -OCH2-X; wherein R is hydrogen...
1. A compound of Formula (I): wherein, R1 and R2 each independently represent H, halogen, CF3, C1-3 alkyl or C1-3 alkoxy; R3 represents C1-6 alkyl, C3-6 cycloalkyl, phenyl which is optionally substituted by one or more substituents each independently selected from Ra; or Het which ...