Background Low-dose interleukin-2 (IL-2) therapy expands regulatory T cells (Treg) and provides clinical benefit for inflammatory diseases. AMG 592 is an investigational IL-2 mutein designed to expand Treg more selectively than recombinant IL-2 (aldesleukin). In a phase 1, double-blind, ...
Background: Low-dose interleukin-2 (IL-2) therapy expands regulatory T cells (Tregs) and provides clinical benefit for inflammatory diseases; however, concomitant increases in conventional effector T cells (Tcon) and natural killer (NK) cells may result in toxicity. AMG 592 is an investigational...
Background: Low-dose interleukin-2 (IL-2) therapy expands regulatory T cells (Tregs) and provides clinical benefit for inflammatory diseases; however, concomitant increases in conventional effector T cells (Tcon) and natural killer (NK) cells may result in toxicity. AMG 592 is an investigational...